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Anti-FASLG / Fas Ligand Antibody (clone MFL4) LS-C188445

Catalog Size Price
LS-C188445-100 100 µg Unavailable

Most Popular FASLG / Fas Ligand Antibodies

Anti-FASLG / Fas Ligand Antibody (clone H11) LS-C18630
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Anti-FASLG / Fas Ligand Antibody (N-Terminus) IHC-plus™ LS-B3325
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Anti-FASLG / Fas Ligand Antibody IHC-plus™ LS-B4195
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Anti-FASLG / Fas Ligand Antibody (clone 2G9-G8) LS-C196679
Mouse Monoclonal [clone 2G9-G8] (IgG2a,k) to Human FASLG / Fas Ligand
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Anti-FASLG / Fas Ligand Antibody (aa102-280, Biotin) LS-C299729
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100% Guaranteed
Hamster Monoclonal [clone MFL4] (IgG) to Mouse FASLG / Fas Ligand
Mouse, Rat
Flow Cytometry (applications tested for the base form of this product only)
Unconjugated

Details

Mouse FASLG / Fas Ligand
Hamster
Mouse, Rat (tested or 100% immunogen sequence identity)
IgG Monoclonal [MFL4]
Unconjugated. Also available conjugated with FITC, RPE.
Protein G purified
Unmodified. Also available Low Endotoxin.

Applications

  • Flow Cytometry (1:25 - 1:200)
  • (applications tested for the base form of this product only)

Specificity and Use

B6 mouse FasL/BHK cells.
Recognizes both mouse and rat CD178, otherwise known as Fas Ligand/ CD95L, a 40kD type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection. CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis. Clone MFL4 is reported to block CD178/CD95 induced apoptosis.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About FASLG / Fas Ligand

P48023 NM_000639 NP_000630.1

FASLG Antibody, ALPS1B Antibody, Apoptosis antigen ligand Antibody, APTL Antibody, CD95L Antibody, CD95 ligand Antibody, CD178 antigen Antibody, CD95-L Antibody, Fas antigen ligand Antibody, Fas ligand Antibody, FASL Antibody, TNFSF6 Antibody, APT1LG1 Antibody, CD178 Antibody

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

Requested From: 
Date Requested: 12/18/2017

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