Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

FANCA

Fanconi anemia, complementation group A

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.

Gene Name: Fanconi anemia, complementation group A
Synonyms: FANCA, FA1, FACA, FA-H, Fanconi anemia group A protein, Fanconi anemia, type 1, FA, Protein FACA, FAA, FANCH
Target Sequences: NM_000135 NP_000126.2 O15360

Publications (6)

1
Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism. Waisfisz Q, Morgan NV, Savino M, de Winter JP, van Berkel CG, Hoatlin ME, Ianzano L, Gibson RA, Arwert F, Savoia A, Mathew CG, Pronk JC, Joenje H. Nature genetics. 1999 22:379-83. [PubMed:10431244]
2
A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. Waisfisz Q, de Winter JP, Kruyt FA, de Groot J, van der Weel L, Dijkmans LM, Zhi Y, Arwert F, Scheper RJ, Youssoufian H, Hoatlin ME, Joenje H. Proceedings of the National Academy of Sciences of the United States of America. 1999 96:10320-5. [PubMed:10468606] [PMC:PMC17886]
3
The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. de Winter JP, van der Weel L, de Groot J, Stone S, Waisfisz Q, Arwert F, Scheper RJ, Kruyt FA, Hoatlin ME, Joenje H. Human molecular genetics. 2000 9:2665-74. [PubMed:11063725]
4
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Meetei AR, Sechi S, Wallisch M, Yang D, Young MK, Joenje H, Hoatlin ME, Wang W. Molecular and cellular biology. 2003 23:3417-26. [PubMed:12724401] [PMC:PMC164758]
5
Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins. Park SJ, Ciccone SL, Beck BD, Hwang B, Freie B, Clapp DW, Lee SH. The Journal of biological chemistry. 2004 279:30053-9. (WB, IP; Human) [PubMed:15138265]
6
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ. Cell. 2007 129:289-301. [PubMed:17412408] [PMC:PMC2175179] Related Antibodies: LS-B70.
more

☰ Filters
Antibodies (34)
Proteins (5)
Over-Expression Lysate (2)
Primary (34)
Recombinant (3)
FANCA (39)
Human (34)
Mouse (3)
Rat (2)
Bovine (3)
Chimpanzee (1)
Monkey (3)
IHC (12)
IHC-P (4)
WB (27)
ELISA (18)
ICC (3)
IF (6)
IP (3)
Peptide-ELISA (2)
rabbit (32)
mouse (2)
Product Group
IHCPlus (3)
IgG (27)
IgG1 (1)
monoclonal mc (1)
polyclonal pc (33)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (23)
aa667-694 (7)
aa71-120 (4)
pSer1149 (4)
1090-1170 aa (2)
N-Terminal (1)
aa1-298 (1)
aa1121-1170 (1)
aa1200-1300 (1)
aa1405-1455 (1)
No (38)
Yes (1)
GST (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
Baculovirus (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
FANCA Antibody - Anti-FANCA antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Human, Chimpanzee
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
FANCA Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
FANCA Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
FANCA Antibody - Immunofluorescent analysis of FANCA (pS1149) staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Select
FANCA Rabbit anti-Human Polyclonal (pSer1149) Antibody
Mouse, Rat, Human
ICC, IF, IP, WB
Unconjugated
100 µl/$315
FANCA Antibody - FANCA Antibody western blot of 293 cell line lysates (35 ug/lane). The FANCA antibody detected the FANCA protein (arrow).
Select
FANCA Rabbit anti-Human Polyclonal (aa667-694) Antibody
Human
WB
Unconjugated
400 µl/$393
FANCA Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using FANCA (Phospho-Ser1149) antibody.
Select
FANCA Rabbit anti-Human Polyclonal (pSer1149) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
FANCA Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using FANCA (Phospho-Ser1149) Antibody. The picture on the right is blocked with the phospho peptide.
Select
FANCA Rabbit anti-Human Polyclonal (pSer1149) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FANCA Antibody - Western blot of Phospho-FANCA (S1149) antibody
Select
FANCA Rabbit anti-Human Polyclonal (1090-1170 aa) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FANCA Antibody - Anti-FANCA antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
FANCA Rabbit anti-Human Polyclonal (aa1121-1170) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
Select
FANCA Rabbit anti-Human Polyclonal (pSer1149) Antibody
Mouse, Rat, Human
ICC, IHC, IP, WB
Unconjugated
50 µl/$328; 100 µl/$419
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
Select
FANCA Rabbit anti-Human Polyclonal (1090-1170 aa) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FANCA Antibody - Immunofluorescent analysis of Hela cells using FANCA Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
Select
FANCA Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
FANCA Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using FANCA antibody.
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$357
FANCA Antibody - Immunohistochemistry of paraffin-embedded human stomach tissue.
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
Select
FANCA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$394
Select
FANCA Rabbit anti-Human Polyclonal (aa667-694) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
FANCA Rabbit anti-Human Polyclonal (aa667-694) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
FANCA Rabbit anti-Human Polyclonal (aa667-694) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
FANCA Rabbit anti-Human Polyclonal (aa667-694) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
FANCA Rabbit anti-Human Polyclonal (aa667-694) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
FANCA Mouse anti-Human Polyclonal (aa1-298) Antibody
Human
IF, WB
Unconjugated
50 µg/$705
Select
FANCA Rabbit anti-Human Polyclonal (aa1405-1455) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Viewing 1-25 of 39 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).