Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
A lipoprotein receptor cluster IV mutant preferentially binds amyloid- beta and regulates its clearance from the mouse brain. Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. The Journal of biological chemistry. 2013 May;288:15154-66. [Full Text Article]
F9 Antibody, Christmas Disease Antibody, Coagulation factor IX Antibody, Factor IX Deficiency Antibody, FIX Antibody, HEMB Antibody, F9 p22 Antibody, Factor 9 Antibody, Factor IX Antibody, Factor IX F9 Antibody, FIX F9 Antibody, Haemophilia B Antibody, THPH8 Antibody, Christmas factor Antibody, Hemophilia B Antibody, PTC Antibody, Serine protease Antibody
F9 / Factor IX is a vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII.