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Anti-F8 / FVIII / Factor VIII Antibody (clone RFF-VIIIC/5) LS-C188518

Catalog Size Price
LS-C188518-500 500 µg (1 mg/ml) Unavailable

Most Popular F8 / FVIII / Factor VIII Antibodies

Anti-F8 / FVIII / Factor VIII Antibody (HRP) LS-C23380
Sheep Polyclonal (IgG) to Human F8 / FVIII / Factor VIII
ELISA, Immunoelectrophoresis
HRP Conjugated
Anti-F8 / FVIII / Factor VIII Antibody IHC-plus™ LS-B2979
Sheep Polyclonal (IgG) to Human F8 / FVIII / Factor VIII
IHC - Paraffin, ELISA, Gel shift
Immunohistochemistry Image
Anti-F8 / FVIII / Factor VIII Antibody (clone F8 2.2.9) IHC-plus™ LS-B3124
Mouse Monoclonal [clone F8 2.2.9] (IgG1) to Human F8 / FVIII / Factor VIII
IHC - Paraffin
Immunohistochemistry Image
Anti-F8 / FVIII / Factor VIII Antibody (aa1790-1839) LS-C135701
Rabbit Polyclonal to Human F8 / FVIII / Factor VIII
Human, Monkey, Bovine, Rabbit, Sheep
Western blot
Western blot Image
Anti-F8 / FVIII / Factor VIII Antibody (Ser2194) LS-C176016
Rabbit Polyclonal to Human F8 / FVIII / Factor VIII
Human, Mouse
Western blot
Western blot Image

100% Guaranteed
Mouse Monoclonal [clone RFF-VIIIC/5] (IgG1) to Human F8 / FVIII / Factor VIII
Western blot, ELISA, Radioimmunoassay


Human F8 / FVIII / Factor VIII
Human (tested or 100% immunogen sequence identity)
Mouse, Rat, Dog
IgG1 Monoclonal [RFF-VIIIC/5]
Protein G purified


  • Western blot
  • ELISA (1:400 - 1:4000)
  • Radioimmunoassay

Specificity and Use

Affinity purified human Factor VIII.
Recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause hemophilia A, a disorder characterized by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Clone RFF-VIIIC/5 recognizes an epitope towards the C-terminus of full-length Factor VIII. It also recognizes the 80kD and 70kD cleavage products.


PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing. Store undiluted.
For research use only.

About F8 / FVIII / Factor VIII

P00451 NM_000132 NP_000123.1

F8 Antibody, AHF Antibody, Antihemophilic factor Antibody, Coagulation factor VIIIc Antibody, Coagulation factor VIII Antibody, DXS1253E Antibody, Factor VIII F8B Antibody, FVIII Antibody, HEMA Antibody, F8B Antibody, Factor VIII Antibody, Procoagulant component Antibody, F8C Antibody

F8 / FVIII / Factor VIII is coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex.

Enzyme-Linked Immunosorbent Assay

Enzyme-Linked Immunosorbent Assay
Recombinant Human Factor VIII detected with Mouse anti-Human Factor VIII

Requested From: 
Date Requested: 3/20/2018

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