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F3 / CD142 / Tissue factor
coagulation factor III (thromboplastin, tissue factor)
F3 / CD142 / Tissue factor is coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
| Gene Name: | coagulation factor III (thromboplastin, tissue factor) |
| Synonyms: | F3, CD142, CD142 antigen, TFA, Tissue factor, Thromboplastin, Coagulation factor III |
| Target Sequences: | NM_001993 NP_001984.1 P13726 |
Publications (4)
1
Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps. Boone BA, Murthy P, Miller-Ocuin J, Doerfler WR, Ellis JT, Liang X, Ross MA, Wallace CT, Sperry JL, Lotze MT, Neal MD, Zeh HJ 3rd. BMC cancer. 2018 June;18:678. [Full Text Article]
[PubMed:29929491]
[PMC:PMC6013899]
2
Procoagulant extracellular vesicles in amniotic fluid. Lena Hell, Lukas Wisgrill, Cihan Ay, Andreas Spittler, Michael Schwameis, Bernd Jilma, Ingrid Pabinger, Peter Altevogt, Johannes Thaler. Translational research : the journal of laboratory and clinical medicine. 2017 June;184:12-20.e1. [Full Text Article]
[PubMed:28236427]
[PMC:PMC6544525]
3
Using annexin V-coated magnetic beads to capture active tissue factor-bearing microparticles from body fluids. Frank Gieseler, Hans Gamperl, Frederike Theophil, Inga Stenzel, Tabea Quecke, Hendrik Ungefroren, Hendrik Lehnert. Cell biology international. 2014 Feburary;38:277-81. [Full Text Article]
[PubMed:24431236]
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F3 / CD142 / Tissue factor
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F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (HTF-1) Antibody
Human
Flo, ICC, IHC-P, WB
Unconjugated
0.05 mg/$460
F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (PE) (HTF-1) Antibody
Human
Flo, Func, ICC, WB
PE Conjugated
100 Tests/$365
F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (Extracellular Domain) (TF9-10H10) Antibody
Human
Flo, IF, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$385
E. coli
His, N-Terminal
26.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Sandwich
96-Well Microplate
Human
6.14 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Microplate
Mouse
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$332
F3 / CD142 / Tissue factor Mouse anti-Rat Monoclonal Antibody
Rat
ICC, IP, WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
F3 / CD142 / Tissue factor Mouse anti-Rat Monoclonal (FITC) Antibody
Rat
ICC, IP, WB
FITC Conjugated
100 µl/$352; 200 µl/$413; 500 µl/$625; 1 ml/$780; 2 ml/$1,018; 5 ml/$1,775
Sandwich
96-Well Microplate
Rabbit
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
F3 / CD142 / Tissue factor Mouse anti-Rabbit Monoclonal (aa33-292) Antibody
Rabbit
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal (aa34-251) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal (aa34-251) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439
F3 / CD142 / Tissue factor Guinea pig anti-Rabbit Polyclonal (aa33-292) Antibody
Rabbit
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
F3 / CD142 / Tissue factor Mouse anti-Mouse Monoclonal (aa30-251) Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$307; 200 µl/$348; 500 µl/$486; 1 ml/$555; 2 ml/$742; 5 ml/$1,205
F3 / CD142 / Tissue factor Mouse anti-Mouse Monoclonal (aa30-251) (Biotin) Antibody
Mouse
ICC, IP, WB
Biotin Conjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,325
F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (CLB/TF-1) Antibody
Human
ELISA, Flo
Unconjugated
0.2 mg/$454
F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
F3 / CD142 / Tissue factor Sheep anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
1 mg/$414
F3 / CD142 / Tissue factor Rabbit anti-Mouse Polyclonal (aa30-251) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
F3 / CD142 / Tissue factor Rabbit anti-Mouse Polyclonal (aa30-251) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated
100 µl/$412
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