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EVX2 is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation.
Gene Name: | even-skipped homeobox 2 |
Synonyms: | EVX2, Even-skipped homeobox 2, EVX-2 |
Target Sequences: | XM_292968 Q03828 Q03828 |
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