Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ETS1 Antibody, Ets protein Antibody, ETS-1 Antibody, EWSR2 Antibody, p54 Antibody, Protein C-ets-1 Antibody
C-ets-1 is a nuclear ETS proto-oncogene product that activate transcription by interaction with purine-rich sequences present in the promoter/enhancer region of the T-Cell antigen receptor (TCRA) gene. In many cancers such as leukemia and lymphomas, the ETS-1 gene is either translocated or rearranged and amplified. In contrast, ectopic expression of ETS-1 in colon cancer cell lines that do not normally express the gene, suppresses tumorigenicity at a transcriptional level.
Confocal immunofluorescence of ETS1 Antibody with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Western blot of lysate from Jurkat cell line, using ETS1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
ETS1 Antibody flow cytometry of Jurkat cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Requested From: United States
Date Requested: 12/8/2016