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ESPL1 / Separase
extra spindle pole bodies homolog 1 (S. cerevisiae)
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).
| Gene Name: | extra spindle pole bodies homolog 1 (S. cerevisiae) |
| Family/Subfamily: | Protease , Cysteine C50 |
| Synonyms: | ESPL1, ESP1, Extra spindle poles like 1, KIAA0165, Caspase-like protein ESPL1, SEPA, Separase, Separin |
| Target Sequences: | NM_012291 NP_036423.4 Q14674 |
Publications (3)
1
Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S. American journal of physiology. Cell physiology. 2007 293:C1082-92.
[PubMed:17626243]
2
Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells. Fujita T, Epperly MW, Zou H, Greenberger JS, Wan Y. Molecular biology of the cell. 2008 19:5446-55.
[PubMed:18843049]
[PMC:PMC2592668]
3
Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner. Kim HS, Jeon YK, Ha GH, Park HY, Kim YJ, Shin HJ, Lee CG, Chung DH, Lee CW. Cancer research. 2009 69:27-36.
[PubMed:19117984]
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(66)
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(1)
ESPL1 / Separase Rabbit anti-Human Polyclonal (Ala795) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
ESPL1 / Separase Rabbit anti-Human Polyclonal (740-820 aa) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ESPL1 / Separase Rabbit anti-Human Polyclonal (aa767-816) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ESPL1 / Separase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ESPL1 / Separase Mouse anti-Human Monoclonal (6H6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer801) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
ESPL1 / Separase Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
ESPL1 / Separase Rabbit anti-Human Polyclonal (p801) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer801) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer801) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ESPL1 / Separase Rabbit anti-Human Polyclonal (740-820 aa) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1126) Antibody
Human
DB, ELISA, IHC
Unconjugated
200 µl/$734
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1126) (Biotin) Antibody
Human
DB, ELISA, IHC
Biotin Conjugated
200 µl/$952
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1126) (Azide-free) (HRP) Antibody
Human
DB, ELISA, IHC
HRP Conjugated, Azide-free
200 µl/$952
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1126) (APC) Antibody
Human
DB, ELISA, IHC
APC Conjugated
200 µl/$952
![ESPL1 / Separase Antibody - Overlay [blue] of centrosomal staining in HeLa cells. Centrosomal staining of separase [yellow], using Separase antibody, and gamma tubulin [green] in mitotic-metaphase cells and nuclear staining of separase in pre-mitotic cells.](https://lsbio-7d62.kxcdn.com/image2/espl1-separase-antibody-aa1866-1996-clone-xj11-4d7-ls-c2889/3323_653461.jpg)
ESPL1 / Separase Mouse anti-Human Monoclonal (aa1866-1996) (XJ11-4D7) Antibody
Human
IF, WB
Unconjugated
0.1 ml/$386
ESPL1 / Separase Mouse anti-Human Monoclonal (aa1866-1996) (XJ11-1B12) Antibody
Human
IF, WB
Unconjugated
0.1 ml/$386
ESPL1 / Separase Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer748) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer801) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1501) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1176) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
ESPL1 / Separase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1126) Antibody
IF, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
ESPL1 / Separase Rabbit anti-Human Polyclonal (pSer1126) Antibody
Human
DB, IHC, IHC-P
Unconjugated
400 µl/$393
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product results
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