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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ERN1 / IRE1 Antibody (C‑Terminus) LS‑C8259
IRE1 antibody LS-C8259 is an unconjugated rabbit polyclonal antibody to IRE1 (ERN1) from human, mouse and rat. Validated for WB.
Antibody
Catalog
Size
Price
LS-C8259-100
100 µg
$515

Popular ERN1 / IRE1 Products

Anti-ERN1 / IRE1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B680 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Anti-ERN1 / IRE1 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8029 dilution 5 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Anti-ERN1 / IRE1 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4154 dilution 1:200.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Antibody (0.03 ug/ml) staining of Human Pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
Species: Human, Monkey, Rabbit
Applications: Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Immunocytochemistry of IRE1p in A20 cells with IRE1p antibody at 1 ug/ml.
Species: Human, Mouse, Rat
Applications: ICC, Immunofluorescence, Western blot

Product Description

IRE1 antibody LS-C8259 is an unconjugated rabbit polyclonal antibody to IRE1 (ERN1) from human, mouse and rat. Validated for WB.
About ERN1 / IRE1
The endoribonuclease IRE1/ERN1 encodes the ER-to-nucleus signaling 1 protein, a human homolog of the yeast Ire1 gene product. In S. cerevisiae, as well as in human, this ER transmembrane IRE serine/threonine protein kinase monitors the status of unfolded proteins inside the ER lumen in response to stress. Activation of ERN1 leads to oligomerization, autophosphorylation, and proteolytic cleavage. O75460 NM_001433 NP_001424.3

ERN1 Antibody, ER to nucleus signalling 1 Antibody, Inositol-requiring enzyme 1 Antibody, Inositol-requiring protein 1 Antibody, Ire1-alpha Antibody, IRE1a Antibody, HIRE1p Antibody, IRE1 Antibody, Inositol-requiring 1 Antibody, IRE1P Antibody


Specifications

Target
Human ERN1 / IRE1
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1 - 2 µg/ml)
Immunogen
ERN1 / IRE1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IRE1p (Genbank accession No. O75460).
Epitope
C-Terminus
Specificity
Recognizes human IRE1p. Species cross-reactivity: mouse and rat.
Usage
Suitable for use in Western Blot. Western Blot: 1-2 ug/ml. Positive control: A-20 cell lysate.
Presentation
PBS, pH 7.2, 0.02% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.

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Requested From: United States
Date Requested: 9/18/2018

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