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RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Gene Name: | exoribonuclease 1 |
Synonyms: | ERI1, 3 exoribonuclease, 3'HEXO, 3-5 exonuclease ERI1, 3HEXO, 3-5 exoribonuclease 1, 3EXO, Exoribonuclease 1, Histone mRNA 3-exonuclease 1, Protein 3hExo, THEX1, Eri-1 homolog, HEXO, Three prime mRNA exonuclease 1 |
Target Sequences: | NM_153332 NP_699163.2 Q8IV48 |
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