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Anti-ERBB2 / HER2 Antibody (N-Terminus) IHC-plus™ LS-A9396

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Rabbit Polyclonal to Human ERBB2 / HER2
Human, Monkey, Bovine, Dog, Horse
IHC - Paraffin
Unconjugated

Details

Human ERBB2 / HER2
Rabbit
Human, Monkey, Bovine, Dog, Horse (tested or 100% immunogen sequence identity)
Bat, Pig (at least 90% immunogen sequence identity)
Polyclonal
Immunoaffinity purified

Applications

IHC - Paraffin (5 - 10 µg/ml)

Specificity and Use

ERBB2 / HER2 antibody was raised against synthetic 13 amino acid peptide from N-terminal extracellular domain of human ERBB2 / HER2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Dog, Horse (100%); Bat, Elephant, Pig (92%); Panda, Opossum (85%).
LS-E29631 - Liquid - 50 µg - $145.00
N-Terminus
Human ERBB2 / HER2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.

Packaging

PBS, less than 0.1% sodium azide.
Long term: -70°C; Short term: +4°C
For research use only.

About ERBB2 / HER2

P04626 NM_004448 NP_004439.2

ERBB2 Antibody, C-erb B2/neu protein Antibody, CD340 Antibody, HER2 Antibody, Herstatin Antibody, MLN 19 Antibody, HER-2 Antibody, Neu Antibody, NGL Antibody, Proto-oncogene c-ErbB-2 Antibody, Proto-oncogene Neu Antibody, CD340 antigen Antibody, MLN19 Antibody, p185erbB2 Antibody, TKR1 Antibody

A tyrosine kinase receptor in the EGF-receptor family. ErbB2 does not bind ligand on its own, but acts as an amplifier in heterodimers with ErbB1, (EGFR), ErbB3, or ErbB4. Amplification of the ErbB2 gene and overexpression of ErbB2 protein is associated with breast cancer (~25% of cases), and anti-ErbB2 therapeutics (e. g. Herceptin, an anti-ErbB2 monoclonal antibody) are sometimes effective in treating these cases. Overexpression of ErbB2 has also been indicated as a factor in prostate cancer.

Immunohistochemistry

Immunohistochemistry
Anti-ERBB2 / HER2 antibody LS-A9396 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
 

Requested From: United States
Date Requested: 5/4/2015

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