Target
Human ER Alpha / Estrogen Receptor
Synonyms
ESR1 | Era | ERalpha | Estrogen receptor | ER-alpha | Estrogen receptor 1 | NR3A1 | ER | ESR | ESRA | Estrogen receptor alpha
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Conjugations
Unconjugated
Immunogen
AER304 is a mouse monoclonal IgG1 antibody derived by fusion of Sp2/0-Ag14 mouse myeloma cells with splenocytes from a BALB/c mouse, immunized with estrogen receptor protein purified from calf uterus.
Specificity
The antibody AER304 is directed against estrogen receptor alpha (ER alpha ) and recognizes amino acids residues 120 - 170, an epitope located in the B domain of ER alpha.
Applications
- ICC
- Western blot
- Immunoprecipitation
Usage
Estrogen receptor (ER) is a hormone binding molecule, which belongs to the nuclear hormone family of intracellular receptors. Estrogen receptors exist as alpha and beta forms encoded by separate genes ESR1 and ESR2. ER alpha and ER beta share a high degree of sequence homology and are activated by the hormone 17 beta -estradiol and related compounds, including phytoestrogens and xenoestrogens. Both ER alpha and ER beta function as transcription factors which mediate many of the biological effects of estradiol at the level of gene regulation. Both receptors and are involved in the normal development and function of numerous tissues. Studies also suggest that ER's may be involved in a range of pathological conditions including cancers, neurodegenerative diseases and cardiovascular disease.
Presentation
PBS, 50% glycerol, 0.2% BSA, 0.02% sodium azide
Storage
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ER Alpha / Estrogen Receptor