EPS8

epidermal growth factor receptor pathway substrate 8

Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with DFNB31 and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.

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Antibodies (30)

Proteins (4)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (30)

Recombinant (2)

Sandwich (1)

Target

EPS8 (35)

Reactivity

Human (30)

Mouse (11)

Rat (8)

Bat (4)

Bovine (6)

Chicken (4)

Chimpanzee (6)

Dog (4)

Gibbon (6)

Hamster (3)

Horse (4)

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Orangutan (6)

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IHC (13)

IHC-P (7)

WB (24)

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IP (1)

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rabbit (25)

mouse (4)

goat (1)

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IgG (20)

IgG1,k (1)

IgG3,k (1)

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monoclonal mc (3)

polyclonal pc (27)

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18F1F2 (1)

18F5B11 (1)

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96-Well Strip Plate (1)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Unconjugated (16)

Epitope

aa9-39 (7)

C-Terminus (4)

aa647-696 (4)

aa701-882 (2)

aa761-822 (1)

aa811-822 (1)

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No (34)

Yes (1)

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Plasma (1)

Serum (1)

Tissue Homogenates (1)

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GST (1)

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Human (3)

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EPS8 Antibody (aa9-39) LS-C101290

(4.0) Rating

(1) Publication(s)

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa9-39) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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EPS8 Antibody LS-C665392

Antibody:

EPS8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

EPS8 Antibody LS-C816312

Antibody:

EPS8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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EPS8 Antibody (aa9-39) LS-C327300

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa9-39) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

EPS8 Antibody (aa9-39, Biotin) LS-C219064

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa9-39) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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EPS8 Antibody (aa9-39, FITC) LS-C219065

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa9-39) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

EPS8 Antibody (aa9-39, APC) LS-C219063

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa9-39) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

EPS8 Antibody (aa9-39, Azide-free, HRP) LS-C219066

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa9-39) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

EPS8 Antibody (aa9-39, PE) LS-C219067

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa9-39) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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EPS8 Antibody (aa701-882, clone 18F1F2) LS-C359437

Antibody:

EPS8 Mouse anti-Human Monoclonal (aa701-882) (18F1F2) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$386

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EPS8 Antibody (aa701-882, clone 18F5B11) LS-C359451

Antibody:

EPS8 Mouse anti-Human Monoclonal (aa701-882) (18F5B11) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$386

Select

EPS8 Antibody LS-C670122

Antibody:

EPS8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

EPS8 Antibody (aa761-822) LS-C185353

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa761-822) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

EPS8 Antibody (aa811-822) LS-C54797

Antibody:

EPS8 Goat anti-Human Polyclonal (aa811-822) Antibody

Reactivity:

Chicken, Rabbit, Mouse, Dog, Rat, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

Select

EPS8 Antibody LS-C780318

Antibody:

EPS8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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EPS8 Antibody LS-C809796

Antibody:

EPS8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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EPS8 Antibody (C-Terminus) LS-C201635

Antibody:

EPS8 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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EPS8 Antibody (C-Terminus, HRP) LS-C459022

Antibody:

EPS8 Rabbit anti-Mouse Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Chicken, Zebrafish, Rabbit, Mouse, Dog, Bovine, Pig, Horse, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

EPS8 Antibody (C-Terminus, Biotin) LS-C459020

Antibody:

EPS8 Rabbit anti-Mouse Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Chicken, Zebrafish, Rabbit, Mouse, Dog, Bovine, Pig, Horse, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

EPS8 Antibody (C-Terminus, FITC) LS-C459021

Antibody:

EPS8 Rabbit anti-Mouse Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Chicken, Zebrafish, Rabbit, Mouse, Dog, Bovine, Pig, Horse, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

EPS8 Antibody LS-C783194

Antibody:

EPS8 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$288; 100 µg/$414

Select

EPS8 Antibody (aa647-696) LS-C107741

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa647-696) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

EPS8 Antibody (aa647-696, Biotin) LS-C459017

Antibody:

EPS8 Rabbit anti-Human Polyclonal (aa647-696) (Biotin) Antibody

Reactivity:

Mouse, Bovine, Rat, Hamster, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

EPS8 Antibody LS-C749709

Antibody:

EPS8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

EPS8 Antibody LS-C307409

Antibody:

EPS8 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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