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EPS15

epidermal growth factor receptor pathway substrate 15

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Gene Name: epidermal growth factor receptor pathway substrate 15
Synonyms: EPS15, AF-1P, AF1P, MLLT5, Protein AF-1p, Protein Eps15
Target Sequences: NM_001981 NP_001972.1 P42566

Publications (1)

1
ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination. Marx C, Held JM, Gibson BW, Benz CC. Cancer research. 2010 70:3709-17. (Human) [PubMed:20406983] [PMC:PMC2862137]

☰ Filters
Antibodies (23)
Proteins (5)
Over-Expression Lysate (4)
Primary (23)
Recombinant (1)
EPS15 (28)
Human (23)
Mouse (9)
Rat (7)
Bat (3)
Bovine (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (3)
Pig (3)
Rabbit (3)
IHC (3)
WB (21)
ELISA (10)
IF (2)
IP (2)
Peptide-ELISA (1)
rabbit (23)
IgG (19)
polyclonal pc (23)
APC Conjugated (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (15)
aa840-870 (7)
aa794-843 (4)
pTyr849 (3)
aa575-625 (2)
790-870 aa (1)
aa846-896 (1)
No (28)
Myc-DDK (Flag) (5)
Human (3)
293T Cells (2)
HEK 293 Cells (3)
EPS15 Protein - Purified recombinant protein EPS15 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
98.5 kDa
20 µg/$1,107
EPS15 Antibody - Detection of Human EPS15 by IHC-IF. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-EPS15 used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte Plus 555 (A120-501E) used at a dilution of 1:100.
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EPS15 Rabbit anti-Human Polyclonal (aa575-625) Antibody
Human
IF, IHC
Unconjugated
1 µg/$295; 100 µl/$532
EPS15 Antibody - Detection of Human EPS15 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-EPS15 used at a dilution of 1:200 (1 Detection: DAB.
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EPS15 Rabbit anti-Human Polyclonal (aa575-625) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
EPS15 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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EPS15 Rabbit anti-Human Polyclonal (pTyr849) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
EPS15 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer tissue  using EPS15 Polyclonal Antibody at dilution of 1:50(×200)
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EPS15 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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EPS15 Rabbit anti-Human Polyclonal (aa840-870) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
EPS15 Rabbit anti-Human Polyclonal (aa840-870) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
200 µl/$952
Select
EPS15 Rabbit anti-Human Polyclonal (aa840-870) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
EPS15 Rabbit anti-Human Polyclonal (aa840-870) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
EPS15 Rabbit anti-Human Polyclonal (aa840-870) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
EPS15 Rabbit anti-Human Polyclonal (aa840-870) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
EPS15 Antibody - Western blot of Phospho-Eps15 (Y849) antibody
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EPS15 Rabbit anti-Human Polyclonal (790-870 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
EPS15 Antibody - Western blot analysis of extracts from HepG2 cells, using EPS15 (Phospho-Tyr849) antibody.
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EPS15 Rabbit anti-Human Polyclonal (pTyr849) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
EPS15 Antibody - Western blot - Anti-EPS15 antibody
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EPS15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
Select
EPS15 Rabbit anti-Human Polyclonal (aa846-896) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
EPS15 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EPS15 Rabbit anti-Human Polyclonal (aa794-843) Antibody
Human
WB
Unconjugated
100 µl/$424
EPS15 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EPS15 Rabbit anti-Human Polyclonal (aa794-843) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
EPS15 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EPS15 Rabbit anti-Human Polyclonal (aa794-843) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
EPS15 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EPS15 Rabbit anti-Human Polyclonal (aa794-843) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
EPS15 Antibody - Western blot of anti-EPS15 antibody in HL60 cell line lysate (35 ug/lane). EPS15 (arrow) was detected using the purified antibody.
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EPS15 Rabbit anti-Human Polyclonal (aa840-870) Antibody
Human
WB
Unconjugated
400 µl/$393
EPS15 Antibody
Select
EPS15 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
EPS15 Antibody - Western blot analysis of extracts of various cell lines.
Select
EPS15 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
EPS15 Antibody - Western blot of HepG2 cell lysate using Phospho-EPS15(Tyr849) Antibody
Select
EPS15 Rabbit anti-Human Polyclonal (pTyr849) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
EPS15 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY EPS15. (Right lane) cDNA for 48 hrs and lysed
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EPS15 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$414
EPS15 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
64.2 kDa
100 µg/$494
Viewing 1-25 of 28 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).