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EPHA5 / EPH Receptor A5
EPH receptor A5
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
| Gene Name: | EPH receptor A5 |
| Family/Subfamily: | Protein Kinase , Ephrin Receptor |
| Synonyms: | EPHA5, BSK, Brain-specific kinase, EHK-1, EK7, Eph homology kinase-1, EPH receptor A5, EPH-like kinase 7, EHK1, HEK7, Els1, EPH homology kinase 1, Rek7, TYRO4, CEK7, Ephrin type-A receptor 5 |
| Target Sequences: | NM_004439 CAA64700.1 P54756 |
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