Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone 3G10] (IgG2b) to Human Endothelin
IHC - Frozen, Radioimmunoassay
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [3G10]
Protein G purified
IHC - Frozen
Specificity and Use
Endothelin antibody was raised against synthetic peptide corresponding to the c-terminal region of human endothelin (C, H, L, D, I, I, W), conjugated to BSA.
Reacts with the C terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin. The endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.
Immunohistology: Frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.