Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Hamster Monoclonal [clone MH1] (IgG) to Human EMA / MUC1
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry
Human EMA / MUC1
Human, Monkey (tested or 100% immunogen sequence identity)
Rabbit (at least 90% immunogen sequence identity)
IgG Monoclonal [MH1]
Protein G purified
IHC - Paraffin (1 - 2 µg/ml)
Specificity and Use
EMA / MUC1 antibody was raised against a Synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Rabbit (94%); Mouse, Rat, Hamster, Bat, Horse (88%).
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
EMA / MUC1 is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas.
Formalin-fixed, paraffin-embedded human breast cancer stained with alkaline phosphatase-conjugate and fast red chromogen. Note nuclear and cytoplasmic staining of tumor cells. This image was taken for the unmodified form of this product. Other forms have not been tested.