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EIF5A

eukaryotic translation initiation factor 5A

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Gene Name: eukaryotic translation initiation factor 5A
Synonyms: EIF5A, EIF-4D, EIF-5A, EIF-5A-1, EIF-5A1, EIF5A1, Initiation factor 5a, Rev-binding factor, EIF5AI
Target Sequences: NM_001970 NP_001961.1 P63241

Publications (2)

1
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. YongTian Liang, Chengji Piao, Christine B Beuschel, David Toppe, Laxmikanth Kollipara, Boris Bogdanow, Marta Maglione, Janine Lützkendorf, Jason Chun Kit See, Sheng Huang, Tim O F Conrad, Ulrich Kintscher, Frank Madeo, Fan Liu, Albert Sickmann, Stephan J Sigrist. Cell reports. 2021 April;35:108941. [Full Text Article] [PubMed:33852845] Related Antibodies: LS-C186978.
2
The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death-induced renal injuries in a preclinical porcine kidney transplantation model. Sebastien Giraud, Thomas Kerforne, Jeremy Zely, Virginie Ameteau, Pierre Couturier, Michel Tauc, Thierry Hauet. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 December;20:3326-3340. [Full Text Article] [PubMed:32400964] Related Antibodies: LS-C186978.

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Antibodies (38)
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EIF5A (54)
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rabbit (25)
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EIF5A Antibody - Western blot of Human NCI-H226. EIF5A antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EIF5A Rabbit anti-Human Polyclonal (aa63-112) Antibody
Human
WB
Unconjugated
100 µl/$424
EIF5A Antibody - Western blot of Human NCI-H226. EIF5A antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EIF5A Rabbit anti-Human Polyclonal (aa63-112) (HRP) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Guinea pig, Rat, Pig, Horse, Chimpanzee, Human
WB
HRP Conjugated
100 µl/$469
EIF5A Antibody - Immunohistochemistry of paraffin-embedded human kidney using EIF5A antibody at dilution of 1:200 (200x lens).
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EIF5A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
EIF5A Antibody - Anti-EIF5A antibody IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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EIF5A Goat anti-Human Polyclonal (aa13-27) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
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EIF5A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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EIF5A Mouse anti-Human Monoclonal (4E10G8) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
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EIF5A Rabbit anti-Human Polyclonal Antibody
Human
IP
Unconjugated
100 µl/$749
EIF5A Antibody - ICC/IF analysis of EIF5A in Balb/3T3 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human EIF5A antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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EIF5A Mouse anti-Human Monoclonal (AT4D1) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
EIF5A Antibody - Immunofluorescence of monoclonal antibody to EIF5A on HeLa cell . [antibody concentration 10 ug/ml]
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EIF5A Mouse anti-Human Monoclonal (8C1) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
EIF5A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
EIF5A Protein - Purified recombinant protein EIF5A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
20 µg/$1,107
EIF5A Protein
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E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
EIF5A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
100 µg/$494
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EIF5A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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EIF5A Mouse anti-Human Monoclonal (4E10F6) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
EIF5A Antibody - 1:100 staining human spleen tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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EIF5A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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EIF5A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
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EIF5A Mouse anti-Human Monoclonal (aa66-154) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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EIF5A Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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EIF5A Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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EIF5A Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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EIF5A Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
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EIF5A Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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EIF5A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
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EIF5A Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
Viewing 1-25 of 54 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).