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Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa |
Synonyms: | EIF2B4, DKFZP586J0119, EIF2BD, EIF-2B, EIF2B, EIF2Bdelta |
Target Sequences: | NM_015636 NP_056451.3 Q9UI10 |
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