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Anti-EIF2AK2 / PKR Antibody (phospho-Thr446) LS-C17481


Wt. Vol. Conc. Price
100 µg - - $560
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

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Rabbit Polyclonal (IgG) to Human EIF2AK2 / PKR
Western blot


Human EIF2AK2 / PKR
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Protein A purified


Western blot

Specificity and Use

EIF2AK2 / PKR antibody was raised against kLH-conjugated, synthetic peptide corresponding to aa surrounding Thr446 of human PKR.
Recognizes human phospho-PKR, Mr ~68kD. A non-specific protein was also detected, Mr ~75kD which is inhibited by the immunizing peptide.
Suitable for use in Western Blot and Beadlyte Peptide Specificity Assay. Western Blot Analysis: 0.5-2.0 ug/ml of this lot detected phospho-PKR in RIPA lysates from HeLa cells that had been stimulated with IFN alpha overnight followed by treatment with calyculin A for 15 minutes. Beadlyte Peptide Specificity Assay: 0.2-1.0 ug/ml of this lot were incubated with a cocktail of microspheres conjugated to either the phosphorylated or non phosphorylated peptides. Unbound antibody was then removed by filtration, and bound antibody detected with a biotin-conjugated anti-rabbit secondary antibody followed by a phycoerythrin streptavidin conjugate. Fluorescence was read on a Luminex 100 instrument. Median Fluorescence Intensity (MFI) is plotted.


0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide, 30% glycerol.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About EIF2AK2 / PKR

P19525 NM_002759 NP_002750.1

EIF2AK2 Antibody, p1/eIF-2A protein kinase Antibody, p68 kinase Antibody, PRKR Antibody, EIF-2A protein kinase 2 Antibody, p68 Antibody, Protein kinase RNA-activated Antibody, Tik Antibody

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1).

Requested From: United States
Date Requested: 10/21/2016

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