EIF2AK2 / PKR

eukaryotic translation initiation factor 2-alpha kinase 2

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.

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Products

Antibodies (78)

Proteins (14)

ELISA Kits (9)

Type

Cell-Based (1)

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Over-Expression Lysate (6)

Primary (78)

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Sandwich (4)

Target

EIF2AK2 / PKR (101)

Reactivity

Human (75)

Mouse (24)

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Chimpanzee (6)

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Peptide-ELISA (9)

Host

rabbit (74)

mouse (4)

Product Group

IHCPlus (3)

Isotype

IgG (35)

IgG1 (1)

IgG1,k (2)

IgG2a,k (1)

Clonality

monoclonal mc (4)

polyclonal pc (74)

Clone

1441CT628.33.40 (1)

1B9 (1)

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aa205-495 (8)

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Yes (1)

Sample Type

Adherent Cell Cultures (3)

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Serum (3)

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Tag

6His, N-terminus (2)

GST, N-terminus (1)

His, N-Terminal (2)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (7)

Species

Human (9)

Mouse (1)

Rat (1)

Source

293T Cells (3)

E. coli (5)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (3)

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IHC-plus™ EIF2AK2 / PKR Antibody LS-B563

(4.0) Rating

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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EIF2AK2 / PKR Antibody (clone 1441CT628.33.40) LS-C356262

Antibody:

EIF2AK2 / PKR Mouse anti-Human Monoclonal (1441CT628.33.40) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

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EIF2AK2 / PKR Antibody (phospho-Thr451) LS-C75195

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr451) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$832

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EIF2AK2 / PKR Antibody (phospho-Thr451) LS-C354070

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr451) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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Human EIF2AK2 / PKR Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G22902

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

63.96 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human EIF2AK2 / PKR Protein (Recombinant His-SUMO) (Full Length) - LS-G20694

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

77.92 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human Phospho-EIF2AK2 / PKR (Thr446) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1605

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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EIF2AK2 / PKR Antibody (C-Terminus) LS-C352730

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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EIF2AK2 / PKR Antibody (aa280-329) LS-C117004

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (aa280-329) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

EIF2AK2 / PKR Antibody (phospho-Thr446) LS-C808474

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr446) Antibody

Reactivity:

Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

Mouse EIF2AK2 / PKR Protein (Recombinant His, N-Terminal) (aa205-495) - LS-G12276

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

37.2 kDa

Price:

50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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EIF2AK2 / PKR Antibody (clone 1B9) LS-C133408

Antibody:

EIF2AK2 / PKR Mouse anti-Human Monoclonal (1B9) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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EIF2AK2 / PKR Antibody LS-C335592

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

IHC-plus™ EIF2AK2 / PKR Antibody LS-B1352

(4.0) Rating

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

EIF2AK2 / PKR Antibody (phospho-Thr451) LS-C17287

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr451) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 Blots/$860

Select

EIF2AK2 / PKR Antibody (phospho-Thr446) LS-C117460

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr446) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

EIF2AK2 / PKR Antibody (aa205-495) LS-C314531

Antibody:

EIF2AK2 / PKR Rabbit anti-Mouse Polyclonal (aa205-495) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161

Select

EIF2AK2 / PKR Antibody (phospho-Thr446) LS-C17480

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr446) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$832

Select

EIF2AK2 / PKR Antibody (phospho-Thr446) LS-C416593

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr446) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

IHC-plus™ EIF2AK2 / PKR Antibody (aa418-467) LS-B7578

(4.0) Rating

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (aa418-467) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$460

Select

EIF2AK2 / PKR Antibody LS-C752559

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

EIF2AK2 / PKR Antibody LS-C801572

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

EIF2AK2 / PKR Antibody (phospho-Thr451) LS-C17477

Antibody:

EIF2AK2 / PKR Rabbit anti-Human Polyclonal (pThr451) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IP, WB

Format:

Unconjugated

Price:

50 µl/$479; 100 µl/$643

Select

EIF2AK2 / PKR Antibody (clone 1D11) LS-C133409

Antibody:

EIF2AK2 / PKR Mouse anti-Human Monoclonal (1D11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

Human EIF2AK2 / PKR (Sandwich ELISA) ELISA Kit - LS-F11338

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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