EGFR

epidermal growth factor receptor

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.

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Select

PathPlus™ EGFR Antibody LS-A9399

Cancer Pathology

Cancer

Fast Shipping

(5.0) Rating

Antibody:

EGFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

IHC-plus™ EGFR Antibody (Internal) LS-B2199

(4.0) Rating

Antibody:

EGFR Sheep anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$595

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EGFR Antibody (Biotin) LS-C525747

Antibody:

EGFR Sheep anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IP, WB

Format:

Biotin Conjugated

Price:

100 µl/$919

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

IHC-plus™ EGFR Antibody (Internal) LS-B2914

(4.0) Rating

Antibody:

EGFR Sheep anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

EGFR Antibody (phospho-Thr693) LS-C356019

Antibody:

EGFR Rabbit anti-Human Polyclonal (pThr693) Antibody

Reactivity:

Chicken, Zebrafish, Bovine, Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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EGFR Antibody (clone 31G7) LS-C312049

Antibody:

EGFR Mouse anti-Human Monoclonal (31G7) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$317; 0.5 ml/$525; 1 ml/$697

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EGFR Antibody (aa27-57) LS-C100292

Antibody:

EGFR Rabbit anti-Human Polyclonal (aa27-57) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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EGFR Antibody (clone 31G7) LS-C95382

Antibody:

EGFR Mouse anti-Human Monoclonal (31G7) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

0.5 ml/$415; 1 ml/$550

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EGFR Antibody (Extracellular Domain, clone ICR10, FITC) LS-C43911

Antibody:

EGFR Rat anti-Human Monoclonal (Extracellular Domain) (FITC) (ICR10) Antibody

Reactivity:

Human

Applications:

Flo

Format:

FITC Conjugated

Price:

0.1 mg/$444

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EGFR Antibody (phospho-Tyr1068) LS-C6640

(4.0) Rating

(1) Publication(s)

Antibody:

EGFR Rabbit anti-Human Polyclonal (pTyr1068) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$717

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EGFR Antibody (aa693-893, clone 5G9B5) LS-C191837

Antibody:

EGFR Mouse anti-Human Monoclonal (aa693-893) (5G9B5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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IHC-plus™ EGFR Antibody LS-B648

(4.0) Rating

Antibody:

EGFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$515

Select

Human EGFR (Sandwich ELISA) ELISA Kit - LS-F10113

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$725

Select

IHC-plus™ EGFR Antibody (Ser1070) LS-B11802

(4.0) Rating

Antibody:

EGFR Rabbit anti-Human Polyclonal (Ser1070) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

Select

Human EGFR Protein (Recombinant His, C-Terminal) - LS-G27253

Source:

CHO Cells

Tag:

His, C-Terminal

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

95-115 kDa (SDS-PAGE)

Price:

50 µg/$402; 10 µg/$296; 1 mg/$1,933

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EGFR Antibody (aa986-1035) LS-C117640

Antibody:

EGFR Rabbit anti-Human Polyclonal (aa986-1035) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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EGFR Antibody (Ser1166) LS-C177654

Antibody:

EGFR Rabbit anti-Human Polyclonal (Ser1166) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

IHC-plus™ EGFR Antibody (Internal) LS-B14295

(4.0) Rating

Antibody:

EGFR Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Rat, Pig, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

EGFR Antibody (phospho-Tyr1173) LS-C6611

(4.1) Rating

(2) Publication(s)

Antibody:

EGFR Mouse anti-Human Monoclonal (pTyr1173) Antibody

Reactivity:

Mouse, Dog, Rat, Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$845

Select

EGFR Antibody LS-C6625

(4.0) Rating

(1) Publication(s)

Antibody:

EGFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$702

Select

EGFR Antibody (Extracellular Domain, clone ICR10) LS-C43910

Antibody:

EGFR Rat anti-Human Monoclonal (Extracellular Domain) (ICR10) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-Fr, IP

Format:

Unconjugated

Price:

0.2 mg/$486

Select

Mouse EGFR (Sandwich ELISA) ELISA Kit - LS-F5373

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

Select

Human EGFR (Sandwich ELISA) ELISA Kit - LS-F70

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

2.743 - 666.7 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$588

Select

EGFR Antibody (aa1004-1033, APC) LS-C213690

Antibody:

EGFR Rabbit anti-Human Polyclonal (aa1004-1033) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

IHC-plus™ EGFR Antibody (Internal) LS-B16091

(4.0) Rating

Antibody:

EGFR Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Zebrafish, Pig, Bovine, Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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