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Anti-EGFR Antibody (clone 31G7) LS-C95382

Catalog Size Price
LS-C95382-0.5 0.5 ml Unavailable
LS-C95382-1 1 ml Unavailable

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100% Guaranteed
Mouse Monoclonal [clone 31G7] (IgG1) to Human EGFR
Human
IHC
Unconjugated

Details

Human EGFR
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [31G7]
Unconjugated
Ascites
Unmodified

Applications

IHC

Specificity and Use

EGFR antibody was raised against human EGFR derived from A-431 cell line.
The epidermal growth factor receptor (EGFR) is a 170 kD transmembrane protein consisting of an extracellular EGF-binding domain, a short transmembrane region and an intracellular domain with ligand-activated tyrosine kinase activity. EGFR is expressed in many normal epithelial tissues, particularly in the basal layers of stratified epithelium and in squamous epithelium. Over expression of EGFR has been observed in many types of neoplasia, as a result of gene amplification and/or increased protein transcription.

Packaging

less than 0.1% sodium azide
Store at 2-8°C. Do not freeze.
For research use only.

About EGFR

P00533 NM_005228 NP_005219.2

EGFR Antibody, EGFf receptor Antibody, ERBB Antibody, ERBB1 Antibody, MENA Antibody, PIG61 Antibody, Proto-oncogene c-ErbB-1 Antibody, V-erb-b homolog Antibody, EGF-R Antibody, HER1 Antibody

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues.

Requested From: 
Date Requested: 5/22/2018

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