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EFTUD1
Elongation Factor Tu GTP Binding Domain Containing 1
Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.
| Gene Name: | Elongation Factor Tu GTP Binding Domain Containing 1 |
| Synonyms: | EFTUD1, Elongation factor-like 1, HsT19294, Protein FAM42A, RIA1, EFL1, FAM42A, Ribosome assembly 1 homolog |
| Target Sequences: | NM_024580 NP_078856.4 Q7Z2Z2 |
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