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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EDNRB / Endothelin B Receptor Antibody (C‑Terminus) IHC‑plus™ LS‑A57
Endothelin B Receptor antibody LS-A57 is an unconjugated rabbit polyclonal antibody to Endothelin B Receptor (EDNRB) from human, mouse, rat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A57-50
50 µg (1 mg/ml)
$425
In Stock for Immediate Shipment

Popular EDNRB / Endothelin B Receptor Products

Anti-EDNRB antibody LS-A54 IHC of human adrenal, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Anti-EDNRB antibody LS-A55 IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Species: Human, Mouse, Rat
Applications: IHC, Western blot

Product Description

Endothelin B Receptor antibody LS-A57 is an unconjugated rabbit polyclonal antibody to Endothelin B Receptor (EDNRB) from human, mouse, rat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.

Specifications

Target
Human EDNRB / Endothelin B Receptor
Synonyms
EDNRB, ABCDS, Endothelin B receptor, Etb receptor, ET-B, Et-b receptor, Et-b-r, ET-RB, ETBR, ETRB, Etb-svr, WS4A, Endothelin receptor type B, ET-BR, ETB, HSCR, HSCR2
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bovine, Dog, Goat, Hamster, Pig, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Bat, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (8 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 19 amino acid peptide from C-terminus of human EDNRB. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Goat, Hamster, Panda, Bovine, Dog, Rabbit, Pig, Opossum, Platypus (100%); Elephant, Bat, Horse (95%).
Blocking Peptide
LS-E29089 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A57. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About EDNRB / Endothelin B Receptor
The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. P24530 NM_000115 NP_000106.1


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Immunohistochemistry

Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB antibody LS-A57 IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: United States
Date Requested: 10/22/2018

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