E6AP / UBE3A

ubiquitin protein ligase E3A

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.

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Products

Antibodies (39)

Proteins (12)

ELISA Kits (7)

Type

Over-Expression Lysate (4)

Primary (39)

Recombinant (8)

Sandwich (6)

Sandwich CLIA (1)

Target

E6AP / UBE3A (58)

Reactivity

Human (44)

Mouse (10)

Rat (9)

Bat (6)

Bovine (3)

Chicken (3)

Chimpanzee (6)

Dog (3)

Drosophila (3)

Gibbon (6)

Guinea pig (3)

Horse (3)

Monkey (7)

Orangutan (6)

Pig (3)

Rabbit (3)

Zebrafish (6)

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Application

IHC (14)

IHC-P (8)

WB (32)

Flo (1)

ELISA (9)

ICC (2)

IF (5)

IP (2)

Host

rabbit (38)

mouse (1)

Product Group

IHCPlus (1)

Isotype

IgG (19)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (38)

Clone

2F6 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (5)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (2)

Preservative Free (1)

Unconjugated (18)

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Epitope

aa158-407 (8)

aa836-865 (7)

C-Terminus (4)

aa180-229 (4)

aa1-851 (1)

aa34-422 (1)

aa342-585 (1)

aa400-450 (1)

aa75-125 (1)

Publications

No (58)

Sample Type

Cell Lysates (1)

Plasma (6)

Serum (6)

Tissue Homogenates (2)

Tag

6His, N-terminus (2)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (6)

Species

Human (7)

Mouse (3)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Mammalian Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (5)

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E6AP / UBE3A Antibody (clone 2F6) LS-C133508

Antibody:

E6AP / UBE3A Mouse anti-Human Monoclonal (2F6) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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E6AP / UBE3A Antibody LS-C482305

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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E6AP / UBE3A Antibody (aa836-865) LS-C99579

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa836-865) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F20296

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human E6AP / UBE3A (CLIA) ELISA Kit - LS-F29813

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F4413

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Human E6AP / UBE3A Protein (Recombinant His, N-Terminal) (Ser158-Leu407) - LS-G13311

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.1 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F35509

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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E6AP / UBE3A Antibody (aa180-229) LS-C110728

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa180-229) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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E6AP / UBE3A Antibody (C-Terminus) LS-C110729

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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E6AP / UBE3A Antibody LS-C408348

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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E6AP / UBE3A Antibody (aa1-851) LS-C19980

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa1-851) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$450

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IHC-plus™ E6AP / UBE3A Antibody (aa342-585) LS-B14302

(4.0) Rating

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa342-585) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Monkey E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F48951

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.31 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse E6AP / UBE3A Protein (Recombinant 6His, N-terminus) (aa547-875) - LS-G57277

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F12892

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

E6AP / UBE3A Antibody LS-C815077

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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E6AP / UBE3A Antibody (Preservative Free) LS-C814803

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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E6AP / UBE3A Antibody (aa836-865) LS-C123428

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa836-865) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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E6AP / UBE3A Antibody (aa836-865, Biotin) LS-C225266

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa836-865) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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E6AP / UBE3A Antibody (aa836-865, FITC) LS-C225267

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa836-865) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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E6AP / UBE3A Antibody (aa836-865, APC) LS-C225265

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa836-865) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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E6AP / UBE3A Antibody (aa836-865, Azide-free, HRP) LS-C225268

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa836-865) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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E6AP / UBE3A Antibody (aa836-865, PE) LS-C225269

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal (aa836-865) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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E6AP / UBE3A Antibody LS-C661394

Antibody:

E6AP / UBE3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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