Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DXO Antibody, Dom-3 homolog Z Antibody, DOM3L Antibody, Dom-3 homolog Z (C. elegans) Antibody, DOM3Z Antibody, DOM-3 (C. elegans) homolog Z Antibody, NG6 Antibody, Protein Dom3Z Antibody, decapping and exoribonuclease protein Antibody
Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs.
Western blot of DOM3Z (arrow) using rabbit polyclonal DOM3Z Antibody (N-term Y88). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DOM3Z gene.
Western blot of DOM3Z antibody (N-term Y88) in MCF-7 cell line lysates (35 ug/lane). DOM3Z (arrow) was detected using the purified antibody.
Flow cytometric of MDA-231 cells using DOM3Z Antibody (N-term Y88)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.