Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DVL3 is a member of multigene family that also contains DVL1 and DVL2. The vertebrate dishevelled proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL3 encodes a predicted 716-amino acid polypeptide that shows 74% nucleotide similarity with human DVL1. Similarity is particularly high in the N-terminal region and there is more divergence in the C-terminal regions. Charcot-Marie-Tooth type 2B maps to chromosome 3q.
Western blot of DVL-3 in breast tumor lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148659 at 2 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Requested From: United States
Date Requested: 2/25/2017