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DUX4
double homeobox 4
DUX4 is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants.
| Gene Name: | double homeobox 4 |
| Synonyms: | DUX4, Double homeobox protein 10, Double homeobox protein DUX10, Double homeobox 4, Double homeobox protein 4/10, Double homeobox protein 4, DUX10 |
| Target Sequences: | NM_033178 NP_149418.3 Q9UBX2 |
Publications (3)
1
Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene. Snider L, Geng LN, Lemmers RJ, Kyba M, Ware CB, Nelson AM, Tawil R, Filippova GN, van der Maarel SM, Tapscott SJ, Miller DG. PLoS genetics. 2010 6:e1001181.
[PubMed:21060811]
[PMC:PMC2965761]
2
Immunodetection of human double homeobox 4. Geng LN, Tyler AE, Tapscott SJ. Hybridoma (2005). 2011 30:125-30.
[PubMed:21529284]
[PMC:PMC3132944]
3
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, et al. Nature genetics. 2016 December;48:1481-1489. (Human)
[Full Text Article]
[PubMed:27776115]
[PMC:PMC5144107]
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(45)
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(18)
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(6)
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(18)
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(38)
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(16)
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(4)
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(17)
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(27)
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(2)
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(17)
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(17)
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(27)
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(11)
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(7)
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(7)
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(4)
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(4)
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(45)
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GST
(1)
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Human
(1)
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Wheat Germ Extract
(1)
DUX4 Mouse anti-Human Monoclonal (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (Biotin) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
Biotin Conjugated
100 µg/$475
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (FITC) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
FITC Conjugated
100 µg/$472
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (Atto 488) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
Atto 488 Conjugated
100 µg/$479
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (Atto 594) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
Atto 594 Conjugated
100 µg/$479
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (Atto 390) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
Atto 390 Conjugated
100 µg/$479
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (APC) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
APC Conjugated
100 µg/$478
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (AP) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
AP Conjugated
100 µg/$474
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (RPE) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
RPE Conjugated
100 µg/$477
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (PerCP) (P2B1) Antibody
Human
IF, IHC, IHC-P, WB
PerCP Conjugated
100 µg/$478
DUX4 Mouse anti-Human Monoclonal (C-Terminus) (P4H2) Antibody
Human
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 ml/$386
DUX4 Mouse anti-Human Monoclonal (Biotin) (P4H2) Antibody
Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
DUX4 Mouse anti-Human Monoclonal (DY488) (P4H2) Antibody
Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
DUX4 Mouse anti-Human Monoclonal (DY650) (P4H2) Antibody
Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
DUX4 Mouse anti-Human Monoclonal (DY550) (P4H2) Antibody
Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
DUX4 Rabbit anti-Human Polyclonal (aa376-404) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
DUX4 Rabbit anti-Human Polyclonal (aa81-130) Antibody
Human
WB
Unconjugated
100 µl/$424
DUX4 Rabbit anti-Human Polyclonal (aa246-275) Antibody
Human
WB
Unconjugated
400 µl/$393
Wheat Germ Extract
GST
73.1kDa
2 µg/$439
DUX4 Mouse anti-Human Monoclonal (P2B1) Antibody
Human
IF, IHC
Unconjugated
100 µg/$484
DUX4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
DUX4 Mouse anti-Human Monoclonal (P4H2) Antibody
Human
IF, IHC-Fr, IHC-P
Unconjugated
100 µg/$484
DUX4 Rabbit anti-Human Polyclonal (aa376-404) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
DUX4 Rabbit anti-Human Polyclonal (aa246-275) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
DUX4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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