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DUSP6 / MKP3
dual specificity phosphatase 6
MKP3 / DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
| Gene Name: | dual specificity phosphatase 6 |
| Family/Subfamily: | Protein Phosphatase , Dual specificity MKP |
| Synonyms: | DUSP6, Dual specificity phosphatase 6, MAP kinase phosphatase 3, MKP3, PYST1, RVH6, Mapk phosphatase 3, MKP-3, Phosphatase VH6 |
| Target Sequences: | NM_001946 NP_001937.2 Q16828 |
Publications (2)
1
BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation. Nadine Reischmann, Geoffroy Andrieux, Ricarda Griffin, Thomas Reinheckel, Melanie Boerries, Tilman Brummer. Oncogene. 2020 September;39:6053-6070. [Full Text Article]
[PubMed:32792685]
[PMC:PMC7498370]
2
Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice10<sup> Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan12<sup> Institute of Biotechnology, National Tsing Hua University, Hsinchu, 30013, Taiwan; Department of Medical Science, National Tsing Hua University, Hsinchu, 30013, Taiwan14<sup> Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli. Cherng-Shyang Chang, Yi-Chu Liao, Chih-Ting Huang, Chiao-Mei Lin, Chantal Hoi Yin Cheung, Jhen-Wei Ruan, Wen-Hsuan Yu, Yi-Ting Tsai, I-Jung Lin, Chien-Hsun Huang, Jong-Shian Liou, Ya-Hsien Chou, Hung-Jen Chien, Hsiao-Li Chuang, Hsueh-Fen Juan, Hsuan-Cheng Huang, Hong-Lin Chan, Yu-Chieh Liao, Shiue-Cheng Tang, Yu-Wen Su, Tse-Hua Tan, Andreas J Bäumler, Cheng-Yuan Kao. Cell reports. 2021 Nov;37:110016. [Full Text Article]
[PubMed:34818535]
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DUSP6 / MKP3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
E. coli
His
20 µg/$361; 100 µg/$554; 10 µg/$292; 50 µg/$411; 250 µg/$1,100; 500 µg/$1,579
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa14-201) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
DUSP6 / MKP3 Mouse anti-Human Monoclonal (3G2) Antibody
Human
ELISA, IF, IHC, IHC-P, RNAi, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
DUSP6 / MKP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
DUSP6 / MKP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
DUSP6 / MKP3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$386
DUSP6 / MKP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa61-110) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
DUSP6 / MKP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa58-89) Antibody
Human
ICC, IF, WB
Unconjugated
400 µl/$393
DUSP6 / MKP3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (Leu76) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
DUSP6 / MKP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$379
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa58-89) (Azide-free) Antibody
Human
ELISA, WB
Unconjugated, Azide-free
200 µl/$734
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa59-88) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa59-88) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa59-88) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa59-88) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa59-88) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
DUSP6 / MKP3 Rabbit anti-Human Polyclonal (aa59-88) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
DUSP6 / MKP3 Goat anti-Human Polyclonal (aa221-235) Antibody
Rabbit, Dog, Bovine, Hamster, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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