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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DUSP26 / MKP8 Antibody (Internal) IHC‑plus™ LS‑A6787
MKP8 antibody LS-A6787 is an unconjugated rabbit polyclonal antibody to MKP8 (DUSP26) from human, mouse, bat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A6787-50
50 µg (1 mg/ml)
Unavailable
In Stock for Immediate Shipment

Popular DUSP26 / MKP8 Products

Anti-DUSP26 antibody LS-A6784 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Mouse, Rat, Bovine, Hamster, Horse, Rabbit
Applications: IHC, IHC - Paraffin, ELISA
Anti-MKP-8 / DUSP26 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Rat, Bat, Bovine, Hamster, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Anti-MKP-8 / DUSP26 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Rat, Bat, Bovine, Hamster, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot

Product Description

MKP8 antibody LS-A6787 is an unconjugated rabbit polyclonal antibody to MKP8 (DUSP26) from human, mouse, bat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
About DUSP26 / MKP8
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Q9BV47 NM_024025 NP_076930.1

DUSP26 Antibody, DSP-4 Antibody, NATA1 Antibody, SKRP3 Antibody, MAP kinase phosphatase 8 Antibody, MKP-8 Antibody, DUSP24 Antibody, LDP-4 Antibody, LDP4 Antibody, MKP8 Antibody


Specifications

Target
Human DUSP26 / MKP8
Host
Rabbit
Reactivity
Human, Mouse, Bat, Hamster, Horse (tested or 100% immunogen sequence identity)
Predicted
Monkey, Rat, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 20 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
DUSP26 / MKP8 antibody was raised against synthetic 18 amino acid peptide from internal region of human DUSP26. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Mouse, Bat, Hamster, Elephant, Panda, Horse (100%); Marmoset, Rat, Rabbit, Opossum, Platypus (94%); Bovine, Pig (89%).
Blocking Peptide
LS-E29181 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A6787. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Human DUSP26. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Usage
Immunohistochemistry: LS-A6787 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-A6787 was determined to be 6 ug/ml.
Presentation
PBS, less than 0.1% sodium azide.
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Immunohistochemistry - Paraffin

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

Immunohistochemistry - Paraffin

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

Immunohistochemistry - Paraffin

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

Immunohistochemistry - Paraffin

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

Requested From: 
Date Requested: 7/17/2018

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