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DUSP1 / MKP1
dual specificity phosphatase 1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
| Gene Name: | dual specificity phosphatase 1 |
| Family/Subfamily: | Protein Phosphatase , Dual specificity MKP |
| Synonyms: | DUSP1, 3CH134, Dual specificity phosphatase 1, ERK-inactivating phosphatase, HVH1, MAP kinase phosphatase 1, VH1, PTPN10, CL100, MKP-1, MKP1 |
| Target Sequences: | NM_004417 NP_004408.1 P28562 |
Publications (1)
1
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies. Briana C Prager, Harish N Vasudevan, Deobrat Dixit, Jean A Bernatchez, Qiulian Wu, Lisa C Wallace, Shruti Bhargava, Derrick Lee, Bradley H King, Andrew R Morton, Ryan C Gimple, Melike Pekmezci, Zhe Zhu, Jair L Siqueira-Neto, Xiuxing Wang, Qi Xie, Clark Chen, Gene H Barnett, Michael A Vogelbaum, Stephen C Mack, Lukas Chavez, Arie Perry, David R Raleigh, Jeremy N Rich. Cancer discovery. 2020 November;10:1722-1741. [Full Text Article]
[PubMed:32703768]
[PMC:PMC8194360]
Related Antibodies: LS-C332288.
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DUSP1 / MKP1 Goat anti-Human Polyclonal (aa355-367) Antibody
Chicken, Bovine, Rabbit, Dog, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$485
DUSP1 / MKP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DUSP1 / MKP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Sheep, Bovine, Rabbit, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (aa318-367) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
DUSP1 / MKP1 Mouse anti-Human Monoclonal (4H7) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (pSer296,pSer318) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DUSP1 / MKP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DUSP1 / MKP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DUSP1 / MKP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (pSer296/Ser318) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (300-380 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (p359) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (Gln290) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (300-380 aa) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (pSer359) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (pSer359) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
100 µg/$357
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (aa46-76) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (aa46-76) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (aa46-76) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
DUSP1 / MKP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
DUSP1 / MKP1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
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