DTX3L

deltex 3 like, E3 ubiquitin ligase

Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

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Products

Antibodies (11)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (11)

Recombinant (2)

Target

DTX3L (15)

Reactivity

Human (10)

Application

WB (10)

ELISA (8)

IP (2)

Host

rabbit (10)

mouse (1)

Isotype

IgG (9)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (10)

Clone

1D10 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (6)

Epitope

aa453-482 (7)

aa700-C-term (1)

aa75-125 (1)

Publications

No (15)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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DTX3L Antibody (aa700-C-term) LS-C287683

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa700-C-term) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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DTX3L Antibody (clone 1D10) LS-C133840

Antibody:

DTX3L Mouse anti-Human Monoclonal (1D10) Antibody

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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DTX3L Antibody LS-C665215

Antibody:

DTX3L Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

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DTX3L Antibody (aa453-482) LS-C320967

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa453-482) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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DTX3L Antibody (aa453-482, Biotin) LS-C256338

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa453-482) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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DTX3L Antibody (aa453-482, FITC) LS-C256339

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa453-482) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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DTX3L Antibody (aa453-482, PE) LS-C256340

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa453-482) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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DTX3L Antibody (aa453-482, APC) LS-C256337

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa453-482) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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DTX3L Antibody (aa453-482, Azide-free, HRP) LS-C256341

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa453-482) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

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DTX3L Antibody (aa453-482) LS-C167559

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa453-482) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

DTX3L Antibody (aa75-125) LS-C287681

Antibody:

DTX3L Rabbit anti-Human Polyclonal (aa75-125) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

Human DTX3L Protein (Recombinant GST, N-terminus) (aa3-110) - LS-G63739

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DTX3L Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68633

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.4 kDa

Price:

20 µg/$1,107

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Human DTX3L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82672

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.4 kDa

Price:

20 µg/$150

Select

DTX3L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102234

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.4 kDa

Price:

100 µg/$494

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