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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DTX1 / Deltex Antibody (aa343‑617) LS‑C186262
Deltex antibody LS-C186262 is an unconjugated rabbit polyclonal antibody to human Deltex (DTX1). Validated for ICC, IHC and WB.
Catalog
Size
Price
LS-C186262-100
100 µl (1 mg/ml)
Unavailable

Popular DTX1 / Deltex Products

Formalin-fixed and paraffin-embedded human lymph tissue reacted with DTX1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Flow Cytometry
Antibody
Species: Human
Applications: IHC, Western blot, Flow Cytometry, ELISA
Antibody
Species: Human
Applications: IHC, Western blot, Flow Cytometry, ELISA
Antibody
Species: Human
Applications: IHC, Western blot, Flow Cytometry, ELISA

Product Description

Deltex antibody LS-C186262 is an unconjugated rabbit polyclonal antibody to human Deltex (DTX1). Validated for ICC, IHC and WB.
About DTX1 / Deltex
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Q86Y01 NM_004416 NP_004407.2

DTX1 Antibody, Deltex homolog 1 (Drosophila) Antibody, Deltex1 Antibody, HDTX1 Antibody, Deltex Antibody, HDx-1 Antibody, Protein deltex-1 Antibody


Specifications

Target
Human DTX1 / Deltex
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Mouse, Bovine (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100 - 1:1000)
  • ICC (1:100 - 1:1000)
  • Western blot (1:500 - 1:3000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
DTX1 / Deltex antibody was raised against recombinant fragment corresponding to a region within amino acids 343 and 617 of Deltex1 (SwissProt Q86Y01). Percent identity by BLAST analysis: Human (100%); Bovine (99%); Mouse (98%); Xenopus (86%).
Epitope
aa343-617
Specificity
Human DTX1 / Deltex
Usage
IHC-paraffin: Suggested antigen retrieval using heat mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).
Presentation
0.1 M Tris-glycine, pH 7.0, 20% glycerol, 0.01% Thimerosal
Storage
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.
IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.

Immunocytochemistry

Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.
Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.

Western blot

Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.
Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.

Immunohistochemistry

IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.
IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.

Immunocytochemistry

Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.
Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.

Western blot

Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.
Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.

Immunohistochemistry

IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.
IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.

Immunocytochemistry

Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.
Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.

Western blot

Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.
Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.

Immunohistochemistry

IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.
IHC of paraffin-embedded BT474 xenograft using Deltex1 antibody at 1:500 dilution.

Immunocytochemistry

Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.
Immunofluorescence of methanol-fixed HeLa using Deltex1 antibody at 1:200 dilution.

Western blot

Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.
Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. DTX1 / Deltex antibody diluted at 1:1000.


Requested From: 
Date Requested: 6/23/2018

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