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Anti-DSC1 / Desmocollin 1 Antibody (Intracellular) LS-C22805


Wt. Vol. Conc. Price
50 µg - - Unavailable

Most Popular DSC1 / Desmocollin 1 Antibodies

Anti-DSC1 / Desmocollin 1 Antibody (Intracellular) LS-C22805
Mouse Monoclonal (IgG1) to Human DSC1 / Desmocollin 1
IHC - Paraffin, IHC - Frozen, Western blot
Anti-DSC1 / Desmocollin 1 Antibody (aa659-687) LS-C167539
Rabbit Polyclonal to Human DSC1 / Desmocollin 1
IHC - Paraffin, Western blot, Flow Cytometry
Immunohistochemistry Image
Anti-DSC1 / Desmocollin 1 Antibody (clone Dsc1-U100) LS-C193351
Mouse Monoclonal [clone Dsc1-U100] (IgG1) to Human DSC1 / Desmocollin 1
IHC, Western blot
Anti-DSC1 / Desmocollin 1 Antibody (C-Terminus, Biotin) LS-C225099
Rabbit Polyclonal (IgG) to Human DSC1 / Desmocollin 1
Western blot, ELISA
Biotin Conjugated
Anti-DSC1 / Desmocollin 1 Antibody LS-C403108
Rabbit Polyclonal (IgG) to Human DSC1 / Desmocollin 1
Human, Mouse
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG1) to Human DSC1 / Desmocollin 1
IHC - Paraffin, IHC - Frozen, Western blot


Human DSC1 / Desmocollin 1
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
IgG1 Monoclonal
Protein A purified


  • IHC - Paraffin
  • IHC - Frozen
  • Western blot

Specificity and Use

DSC1 / Desmocollin 1 antibody was raised against synthetic peptide corresponding to sequence present within the intracellular part of human desmocollin 1 (HQTLESVKGVGQGDTGRYATDWQC). Percent identity by BLAST analysis: Human, Gibbon, Monkey (96%); Gorilla (92%); Marmoset (88%).
Antigen recognized in species specific for human. Cell Lines (tested so far) of differentiated cells. All simple epithelia are negative. desmocollin 1; negative with bovine (tested so far) and rodent material. Reacts with 111kD (form 'a') and 103kD (form 'b') polypeptides (desmocollin1 splice forms, both at pI 5.2) from human epidermal desmosomes. Reactivities on Cultured Positive on primary keratinocytes, however, restricted to local piles.
Suitable for use in Immunohistochemistry and Western Blot. Immunohistochemistry (Frozen, Paraffin, HEIR): 1:10 in PBS, pH 7.4; Incubation Time 1 hr at RT or overnight at 4?C. Note: For better resolution on frozen sections preincubation (directly after fixation) with 0.05-0.2% Triton X-100, for 5-10 min, depending on tissue type, is recommended (see ref. 2). Without detergent pretreatment a cytoplasmic component might cross-react (e. g. in fibroblasts). (Paraffin: slight cross-reactivity with a lymphocyte subpopulation is abolished by mild trypsinization after the microwave step. Localization: Localizes Dsc1 present in suprabasal layers of interfollicular epidermis; specific cell layers (e. g. in hair follicle root sheath); Hassall bodies (spheroidal formations of densely packed reticulum-derived cells in the thymus).


Lyophilized powder from PBS, pH 7.4, 0.5% BSA, 0.09% sodium azide.
Restore with 1ml sterile ddH2O
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C.
For research use only.

About DSC1 / Desmocollin 1

Q08554 NM_024421 NP_077739.1

DSC1 Antibody, Desmocollin-1 Antibody, Desmocollin 1 Antibody, Desmosomal glycoprotein 2/3 Antibody, DG2/DG3 Antibody, Cadherin family member 1 Antibody, CDHF1 Antibody

DSC1 / Desmocollin 1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined.

Requested From: 
Date Requested: 4/23/2017

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