Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DNMT3B Antibody, DNA MTase HsaIIIB Antibody, ICF Antibody, ICF1 Antibody, M.HsaIIIB Antibody, DNA methyltransferase HsaIIIB Antibody
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity).
Western blot ofDnmt3b in NIH 3T3celllysate using antibody at4 ug/ml.
Western blot analysis for Dnmt3b using antibody at 2 ug/ml against 10 ug of cell lysates of 293 transfected with mouse Dnmt3a (lane 1) and Dnmt3b (lane 2). A protein band of approximate mol. wt. of 110 kD is only detected in 293 cells transfected with mouse Dnmt3b cDNA.