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DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
| Gene Name: | DNA (cytosine-5-)-methyltransferase 3 alpha |
| Synonyms: | DNMT3A, DNA MTase HsaIIIA, DNMT3A2, DNA methyltransferase HsaIIIA, M.HsaIIIA |
| Target Sequences: | NM_022552 NP_072046.2 Q9Y6K1 |
Publications (12)
1
An essential role for DNA methyltransferase DNMT3B in cancer cell survival. Beaulieu N, Morin S, Chute IC, Robert MF, Nguyen H, MacLeod AR. The Journal of biological chemistry. 2002 277:28176-81. (WB; Human)
[PubMed:12015329]
2
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. Gene. 2002 298:91-9. (Mouse, Human)
[PubMed:12406579]
3
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR. Nature genetics. 2003 33:61-5. (WB; Human)
[PubMed:12496760]
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DNMT3A Mouse anti-Mouse Monoclonal (C-Terminus) (64B1446) Antibody
Mouse, Human
ChrIP, ICC, IHC, WB
Unconjugated
0.1 mg/$386
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) Antibody
Human
WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
DNMT3A Rabbit anti-Human Polyclonal (aa711-912) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$332
DNMT3A Rabbit anti-Human Polyclonal (aa10-118) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
DNMT3A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Bovine, Rat, Human, Monkey
ELISA, IP, WB
Unconjugated
100 µl/$688
DNMT3A Rabbit anti-Human Polyclonal (aa723-752) Antibody
Human
WB
Unconjugated
400 µl/$393
DNMT3A Mouse anti-Mouse Monoclonal (Azide-free) (64B814.1) Antibody
Mouse, Human
ICC, IF, WB
Unconjugated, Azide-free
0.1 mg/$386
DNMT3A Mouse anti-Mouse Monoclonal (64B814.1) Antibody
Mouse, Human
ICC, IHC, WB
Unconjugated
0.1 mg/$386
DNMT3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
DNMT3A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
DNMT3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
DNMT3A Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
DNMT3A Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
50 µl/$317; 100 µl/$375; 200 µl/$473
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
DNMT3A Rabbit anti-Human Polyclonal (aa457-486) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
DNMT3A Mouse anti-Human Monoclonal (4G5F11) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
DNMT3A Rabbit anti-Human Polyclonal (aa31-61) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DNMT3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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