Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DNMT1 Antibody, AIM Antibody, CXXC finger protein 9 Antibody, CXXC9 Antibody, DNA methyltransferase 1 Antibody, DNMT Antibody, DNA methyltransferase HsaI Antibody, DNA MTase HsaI Antibody, HSN1E Antibody, M.HsaI Antibody, MCMT Antibody
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.
Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.