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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DNM1L / DRP1 Antibody (Internal, DY488) LS‑C141465
DRP1 antibody LS-C141465 is a DY488-conjugated rabbit polyclonal antibody to DRP1 (DNM1L) from human and bovine. Validated for IHC and WB.
Catalog
Size
Price
LS-C141465-100
100 µl
Unavailable

Popular DNM1L / DRP1 Products

IHC of paraffin-embedded Human pancreas tissue using anti-DNM1L mouse monoclonal antibody.
Species: Human, Monkey, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
IHC of paraffin-embedded Human endometrium tissue using anti-DNM1L mouse monoclonal antibody.
Species: Human, Monkey, Mouse, Rat, Dog
Applications: IHC, IHC - Paraffin, Western blot
Anti-DNM1L / DRP1 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10175 concentration 10 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Detection of Human and Mouse Drp1 by Western Blot (h and m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug), Jurkat (J; 50 ug) and mouse NIH3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-Drp1 antibody used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. Drp1 was also immunoprecipitated by rabbit anti-Drp1 antibody BL12232, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).
Species: Human, Mouse
Applications: Western blot, Immunoprecipitation
Staining of DRP-1 in mouse embryonic fibroblast post-nuclear extracts.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation

Product Description

DRP1 antibody LS-C141465 is a DY488-conjugated rabbit polyclonal antibody to DRP1 (DNM1L) from human and bovine. Validated for IHC and WB.
About DNM1L / DRP1
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. O00429 NM_012062 NP_036192.2

DNM1L Antibody, DYMPLE Antibody, Dynamin 1-like Antibody, Dynamin-like protein Antibody, Dynamin-like protein 4 Antibody, Dynamin-like protein IV Antibody, DLP1 Antibody, Dnm1p/Vps1p-like protein Antibody, DVLP Antibody, Dynamin-related protein 1 Antibody, DYNIV-11 Antibody, DRP1 Antibody, Dynamin-1-like protein Antibody, VPS1 Antibody, EMPF Antibody, HDYNIV Antibody


Specifications

Target
Human DNM1L / DRP1
Host
Rabbit
Reactivity
Human, Bovine (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
DyLight 488. Also available Unconjugated or conjugated with Biotin, DY650, DY550.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Western blot
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
DNM1L / DRP1 antibody was raised against a synthetic peptide made to an internal region within residues 500-600 of the human protein. [Swiss-Prot# O00429]. Percent identity by BLAST analysis: Bovine (100%).
Epitope
Internal
Specificity
DRP1.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
50 mM sodium borate
Storage
Store at 4°C. Do not freeze.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7263 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Lane 1: DRP1 knockout Lane 2: DRP1 wild type MEFs Stained at 1:500x dilution. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/17/2018

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