DMTN / Dematin

dematin actin binding protein

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

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Products

Antibodies (30)

Proteins (13)

ELISA Kits (1)

Type

Cell-Based (1)

Over-Expression Lysate (8)

Primary (30)

Recombinant (5)

Target

DMTN / Dematin (44)

Reactivity

Human (31)

Mouse (16)

Rat (4)

Bat (3)

Bovine (7)

Chicken (3)

Chimpanzee (6)

Dog (6)

Gibbon (3)

Guinea pig (6)

Hamster (3)

Horse (6)

Monkey (6)

Orangutan (3)

Pig (3)

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Application

IHC (12)

IHC-P (3)

WB (30)

ELISA (12)

ICC (1)

IF (8)

IP (1)

Peptide-ELISA (4)

Host

rabbit (29)

mouse (1)

Isotype

IgG (18)

Clonality

polyclonal pc (30)

Format

96-Well Microplate (1)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (19)

Epitope

aa249-277 (7)

C-Terminus (5)

aa142-191 (4)

pSer403 (4)

330-410 aa (2)

aa225-275 (1)

aa356-405 (1)

p403 (1)

Publications

No (44)

Sample Type

Adherent Cell Cultures (1)

Tag

DDK,C-terminus (1)

GST (1)

Myc-DDK (Flag) (11)

Species

Human (9)

Source

293T Cells (4)

HEK 293 Cells (7)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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DMTN / Dematin Antibody (C-Terminus) LS-C368799

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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DMTN / Dematin Antibody (330-410 aa) LS-C383119

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (330-410 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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DMTN / Dematin Antibody (p403) LS-C822309

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (p403) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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DMTN / Dematin Antibody LS-C801479

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DMTN / Dematin Antibody (phospho-Ser403) LS-C801497

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (pSer403) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DMTN / Dematin Antibody (aa356-405) LS-C117881

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa356-405) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

DMTN / Dematin Antibody LS-C417222

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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DMTN / Dematin Antibody (phospho-Ser403) LS-C417242

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (pSer403) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

DMTN / Dematin Antibody (phospho-Ser403) LS-C198878

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (pSer403) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

DMTN / Dematin Antibody (330-410 aa) LS-C381328

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (330-410 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

DMTN / Dematin Antibody (phospho-Ser403) LS-C822313

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (pSer403) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

DMTN / Dematin Antibody LS-C830022

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

DMTN / Dematin Antibody (aa249-277) LS-C329505

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa249-277) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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DMTN / Dematin Antibody (aa249-277, Biotin) LS-C256740

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa249-277) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

DMTN / Dematin Antibody (aa249-277, FITC) LS-C256741

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa249-277) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

DMTN / Dematin Antibody (aa249-277, APC) LS-C256739

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa249-277) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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DMTN / Dematin Antibody (aa249-277, Azide-free, HRP) LS-C256742

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa249-277) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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DMTN / Dematin Antibody (aa249-277, PE) LS-C256743

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa249-277) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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DMTN / Dematin Antibody LS-C660231

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

DMTN / Dematin Antibody (aa225-275) LS-C763032

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa225-275) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$456

Select

DMTN / Dematin Antibody (aa142-191) LS-C145567

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa142-191) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

DMTN / Dematin Antibody (C-Terminus) LS-C201722

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

DMTN / Dematin Antibody (C-Terminus, Biotin) LS-C465359

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

DMTN / Dematin Antibody (aa249-277) LS-C167783

Antibody:

DMTN / Dematin Rabbit anti-Human Polyclonal (aa249-277) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

DMTN / Dematin Antibody LS-C307935

Antibody:

DMTN / Dematin Mouse anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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