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Anti-DLL4 Antibody (Internal) LS-C42584

Note: This antibody replaces LS-C36157

Ordering

Wt. Vol. Conc. Price
50 µg - 0.5 mg/ml $365

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Rabbit Polyclonal (IgG) to Human DLL4
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Human DLL4
Rabbit
Human (tested or 100% immunogen sequence identity)
Mouse, Rat (at least 90% immunogen sequence identity)
IgG Polyclonal
Affinity purified

Applications

IHC - Paraffin (5 - 15 µg/ml), Western blot (1:300 - 1:1500), ELISA (1:3000 - 1:15000)

Specificity and Use

DLL4 antibody was raised against synthetic peptide corresponding to the internal region of human DLL4.
Internal
Detects human Delta-like ligand 4 (DLL4), also known as Delta-4. DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn led to a decrease in tumor growth, with no apparent toxicity
Western Blot: LS-C42584 detects a band of approximately 74kD in pancreatic cell lysates.

Packaging

PBS, pH 7.2, 0.09% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About DLL4

Q9NR61 NM_019074 NP_061947.1

DLL4 Antibody, Delta-like 4 protein Antibody, Delta like 4 Antibody, Delta-like 4 (Drosophila) Antibody, Delta-like 4 homolog Antibody, Drosophila Delta homolog 4 Antibody, Notch ligand DLL4 Antibody, Delta 4 Antibody, Delta ligand 4 Antibody, Delta-like protein 4 Antibody, Delta4 Antibody, Hdelta2 Antibody, Notch ligand delta-2 Antibody

DELTA-4 (also called delta 4 precursor, delta ligand 4 precursor, Delta-like protein 4, DLL4, Drosophila Delta homolog 4 and notch ligand DLL4 precursor) is a homolog of the Drosophila delta protein. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. DELTA-4 plays a role in the Notch signaling pathway and activates Notch-1 and Notch- 4. DELTA-4 is a membrane protein that is expressed in the vascular endothelium.

Requested From: United States
Date Requested: 6/2/2015

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