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DLL4

delta-like 4 (Drosophila)

Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

Gene Name: delta-like 4 (Drosophila)
Synonyms: DLL4, Delta-like 4 protein, Delta like 4, Delta-like 4 (Drosophila), Delta-like 4 homolog, Drosophila Delta homolog 4, Notch ligand DLL4, Delta 4, Delta ligand 4, Delta-like protein 4, Delta4, Hdelta2, Notch ligand delta-2
Target Sequences: NM_019074 NP_061947.1 Q9NR61

Publications (2)

1
Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. Nature. 2010 467:854-8. (ICC; Human) [PubMed:20944747] Related Antibodies: LS-C19035.
2
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cell host & microbe. 2013 Sep;14:294-305. [Full Text Article] [PubMed:24034615] [PMC:PMC3786442] Related Antibodies: LS-C19035.

☰ Filters
Antibodies (78)
Proteins (13)
ELISA Kits (10)
Custom (3)
Primary (78)
Recombinant (13)
Sandwich (7)
DLL4 (101)
Human (52)
Mouse (33)
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rabbit (53)
mouse (14)
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monoclonal mc (27)
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aa214-330 (8)
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DLL4 Antibody - Anti-Delta-4 Antibody - Immunohistochemistry. Affinity Purified anti-Delta-4 antibody was used at 20 ug/ml to detect Delta-4 in a variety of tissues including colon, liver, skeletal muscle, ovary, pancreas, prostate, testes, thymus, tonsil and uterus. In contrast to reported findings, no staining was observed in vascular tissue. This image shows Delta-4 staining of human ovary. Tissue was formalin-fixed and paraffin embedded. Personal Communication, Tina Roush, LifeSpanBiosciences, Seattle, WA.
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DLL4 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$567
DLL4 Antibody - IHC with DLL4 antibody on frozen human tonsil.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DLL4 Rabbit anti-Human Polyclonal (aa146-195) Antibody
Human
IHC, IHC-Fr, WB
Unconjugated
50 µl/$460
DLL4 Antibody - IHC with DLL4 antibody on frozen human tonsil.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DLL4 Rabbit anti-Human Polyclonal (aa146-195) (FITC) Antibody
Mouse, Dog, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-Fr, WB
FITC Conjugated
100 µl/$469
DLL4 Antibody - IHC of paraffin-embedded rectum cancer tissues using DLL4 mouse monoclonal antibody with DAB staining.
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DLL4 Mouse anti-Human Monoclonal (4A11F8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$459
DLL4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
DLL4 Protein - Adipogenesis inhibition of 3T3L-1 cells. 3T3L-1 Cells(mouse pre-adipocyte cells) were maintained in DMEM, supplemented with 10% fetal bovine serum and penicillin-streptomycin. For differentiation of 3T3L-1 Cells, 3T3L-1 Cells were cultured in adipogenic medium which was growth medium supplemented with 1 uM Dexamethasone, 0.5mM IBMX, 10 ug/ml lnsulin (day 0). Medium was changed every 2 days. Staining with Oil Red O was typically performed on day 7. Cells were washed twice with PBS, fixed with 3.7% formalin, and stained with 0.5% filtered Oil Red O in propylene glycol. For negative controls, mouse TNF-alpha (20ng/ml) was added. Recombinant human DLL4-Fc (5 ug/ml) dissolved in DPBS was added to the differentiation medium. These plates were then used to differentiate 3T3L-1 Cells.
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HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~80kDa (SDS-PAGE)
50 µg/$519; 10 µg/$379
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
81 kDa
50 µg/$483; 500 µg/$2,504
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DLL4 Hamster anti-Mouse Monoclonal (HMD4-2) Antibody
Mouse
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
0.1 mg/$385; 0.25 mg/$471
DLL4 Protein - Adipogenesis inhibition of 3T3L1 cells. 3T3L1 cells were maintained in DMEM, supplemented with 10% fetal bovine serum, penicilin-streptomycin. Adipogenesis was initiated by adding 1 uM Dexamethasone, 0.5mM IBMX, 10 ug/m lnsulin (day 0) until day 2. The medium was replaced every 2 days with new medium containing insulin in the presence or absence of 5 ug/ml mDLL4-Fc (Prod. No. AG-40A-0145), hTNFalpha and hCD137-Fc (Fc control). Staining with Oil Red O was typically performed on day 7.
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HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
~95kDa (SDS-PAGE)
50 µg/$379; 10 µg/$288
DLL4 Antibody - Western blot using DLL4 monoclonal antibody against human DLL4 (AA: 313-439) recombinant protein. (Expected MW is 39.2 kDa)
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DLL4 Mouse anti-Human Monoclonal (4A11G2) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
DLL4 Antibody - Western blot of DLL4 in HUVEC cell lysate using 1) preimmune sera at 1:5000 and 2) Polyclonal Antibody to DLL4 at 3 ug/ml, and 3) mouse embryo body lysate at 6 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
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DLL4 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$386
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DLL4 Hamster anti-Mouse Monoclonal (12G28) Antibody
Mouse
Flo, IHC
Unconjugated
100 µg/$562; 250 µg/$755
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DLL4 Rabbit anti-Mouse Monoclonal (Preservative Free) (006) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
100 µl/$412
Select
DLL4 Rabbit anti-Mouse Monoclonal (Preservative Free) (004) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
Select
DLL4 Rat anti-Mouse Monoclonal (aa27-525) (Biotin) Antibody
Mouse
ELISA
Biotin Conjugated
250 µg/$1,068
Select
DLL4 Rabbit anti-Human Monoclonal (Preservative Free) (003) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
Select
DLL4 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
DLL4 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$694
DLL4 Antibody - Western blot of DLL4 antibody.
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DLL4 Rabbit anti-Rat Polyclonal (aa215-331) (Cy3) Antibody
Rat
WB
Cy3 Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
DLL4 Antibody - Western blot of recombinant DLL4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DLL4 Rabbit anti-Rat Polyclonal (aa214-330) (Cy3) Antibody
Rat
WB
Cy3 Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
DLL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
23.5 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
DLL4 Protein - Recombinant Delta Like Protein 4 (dLL4) by SDS-PAGE
Select
E. coli
His, N-Terminal
23.4kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
DLL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
DLL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$893
Select
HEK 293 Cells
None
Less than 0.1 ng/µg of protein (less than 1EU/µg).
54.0 kDa
5 µg/$268; 25 µg/$349
Viewing 1-25 of 101 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).