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DLG4 / PSD95
discs, large homolog 4 (Drosophila)
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
| Gene Name: | discs, large homolog 4 (Drosophila) |
| Family/Subfamily: | MAGUK |
| Synonyms: | DLG4, Disks large homolog 4, Presynaptic density protein 95, PSD95, SAP-90, Synapse-associated protein 90, PSD-95, SAP90, Tax interaction protein 15, Discs large homolog 4 |
| Target Sequences: | NM_001365 NP_001356.1 P78352 |
Publications (4)
1
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. Broadhead MJ, Horrocks MH, Zhu F, Muresan L, Benavides-Piccione R, DeFelipe J, Fricker D, Kopanitsa MV, Duncan RR, Klenerman D, Komiyama NH, Lee SF, Grant SG. Scientific reports. 2016 6:24626. (ICC; Human)
[Full Text Article]
[PubMed:27109929]
[PMC:PMC4842999]
2
Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, Wang TL. Frontiers in aging neuroscience. 2016 July;8:175. [Full Text Article]
[PubMed:27493629]
[PMC:PMC4954850]
3
Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota. Jianfeng Liu, Tianhua Zhang, Yingying Wang, Chengqing Si, Xudong Wang, Rui-Tao Wang, Zhonghua Lv. Aging. 2020 February;12:3791-3806. [Full Text Article]
[PubMed:32084011]
[PMC:PMC7066900]
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Neuroscience
DLG4 / PSD95 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
DLG4 / PSD95 Mouse anti-Rat Monoclonal (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Unconjugated
25 µg/$312; 100 µg/$425
DLG4 / PSD95 Mouse anti-Rat Monoclonal (Biotin) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Biotin Conjugated
100 µg/$458
DLG4 / PSD95 Mouse anti-Rat Monoclonal (FITC) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
FITC Conjugated
100 µg/$456
DLG4 / PSD95 Mouse anti-Rat Monoclonal (Atto 390) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Atto 390 Conjugated
100 µg/$463
DLG4 / PSD95 Mouse anti-Rat Monoclonal (Atto 488) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Atto 488 Conjugated
100 µg/$462
DLG4 / PSD95 Mouse anti-Rat Monoclonal (Atto 594) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Atto 594 Conjugated
100 µg/$462
DLG4 / PSD95 Mouse anti-Rat Monoclonal (APC) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
APC Conjugated
100 µg/$461
DLG4 / PSD95 Mouse anti-Rat Monoclonal (AP) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
AP Conjugated
100 µg/$457
DLG4 / PSD95 Mouse anti-Rat Monoclonal Antibody
Mouse, Bovine, Rat, Human
ICC, IF, WB
Unconjugated
25 µg/$488; 100 µg/$672
DLG4 / PSD95 Rabbit anti-Human Polyclonal (aa683-732) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$854
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$893
DLG4 / PSD95 Goat anti-Human Polyclonal (aa667-679) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
81.9kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
DLG4 / PSD95 Mouse anti-Mouse Monoclonal (6G6-1C9) Antibody
Mouse, Bovine, Rat
ICC, WB
Unconjugated
100 µg/$531
DLG4 / PSD95 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DLG4 / PSD95 Mouse anti-Human Monoclonal Antibody
Rat, Human
ICC, IHC, WB
Unconjugated
100 µg/$804
DLG4 / PSD95 Mouse anti-Rat Monoclonal (aa677-706) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$393
DLG4 / PSD95 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$414
DLG4 / PSD95 Mouse anti-Mouse Monoclonal (7E3-1B8) Antibody
Mouse, Bovine, Rat
ICC, IF, WB
Unconjugated
100 µg/$531
DLG4 / PSD95 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
DLG4 / PSD95 Mouse anti-Rat Monoclonal (7E3) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Unconjugated
25 µg/$312; 100 µg/$425
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