Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
DLG4 / PSD95 antibody was raised against recombinant rat PSD-95.
Recognizes a protein of ~100kD, which corresponds to the apparent MW of PSD-95. A slightly higher MW band is also detected. In rat brain and mouse brain tissue extracts a band of ~75kD is also present. Species cross-reactivity: Rat, mouse and bovine.
Suitable for use in Western Blot and Immunocytochemistry. Western Blot: 1-5 ug/ml (ECL). Immunocytochemistry: 12.5 ug/ml.
PBS, pH 7.2, 0.1% sodium azide, 50% glycerol.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
DLG4 Antibody, Disks large homolog 4 Antibody, Presynaptic density protein 95 Antibody, PSD95 Antibody, SAP-90 Antibody, Synapse-associated protein 90 Antibody, PSD-95 Antibody, SAP90 Antibody, Tax interaction protein 15 Antibody, Discs large homolog 4 Antibody
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.