Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DLG4 Antibody, Disks large homolog 4 Antibody, Presynaptic density protein 95 Antibody, PSD95 Antibody, SAP-90 Antibody, Synapse-associated protein 90 Antibody, PSD-95 Antibody, SAP90 Antibody, Tax interaction protein 15 Antibody, Discs large homolog 4 Antibody
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
RAT DLG4 Antibody (Ascites) immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of the RAT DLG4 Antibody (Ascites) for immunohistochemistry.
Western blot of RAT DLG4 Antibody in mouse cerebellum tissue lysates (35 ug/lane). DLG4 (arrow) was detected using the purified antibody.(1:100)