Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DKK1 Antibody, Dickkopf-1 like Antibody, DKK-1 Antibody, Dickkopf-1 Antibody, Dickkopf-related protein 1 Antibody, Dickkopf related protein-1 Antibody, HDkk-1 Antibody, Hdkk1 Antibody, Dickkopf-like protein 1 Antibody, SK Antibody
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Dkk-1 in Mouse Embryo. Dkk-1 was detected in immersion fixed frozen sections of mouse embryo (15 d. p. c) using Mouse Dkk-1 Monoclonal Antibody at 25 ug/ml overnight at 4°C. Tissue was stained using Anti-Rat HRP-DAB (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of epithelial cells in lung.
Requested From: United States
Date Requested: 2/21/2017