DIAPH1

diaphanous-related formin 1

Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

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Antibodies (30)

Proteins (9)

ELISA Kits (1)

Type

Over-Expression Lysate (5)

Primary (30)

Recombinant (4)

Sandwich (1)

Target

DIAPH1 (40)

Reactivity

Human (31)

Mouse (5)

Rat (4)

Bat (4)

Bovine (3)

Dog (3)

Monkey (4)

Rabbit (3)

Application

IHC (8)

IHC-P (3)

WB (29)

ELISA (2)

ICC (1)

IF (1)

IP (2)

Peptide-ELISA (2)

Host

rabbit (28)

mouse (1)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (13)

IgG2b,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (29)

Clone

5A8 (1)

Format

96-Well Strip Plate (1)

APC (1)

APC Conjugated (2)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (15)

Epitope

aa389-583 (8)

aa1196-1245 (4)

aa1200-C-term (2)

aa1-237 (1)

aa1-50 (1)

aa18-52 (1)

aa822-832 (1)

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No (40)

Sample Type

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (7)

Species

Human (7)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

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IHC-plus™ DIAPH1 Antibody (aa1-50) LS-B14783

(4.0) Rating

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$485

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DIAPH1 Antibody (aa1200-C-term) LS-C287015

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa1200-C-term) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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DIAPH1 Antibody (aa822-832) LS-C112650

Antibody:

DIAPH1 Goat anti-Human Polyclonal (aa822-832) Antibody

Reactivity:

Mouse, Rat, Bat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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DIAPH1 Antibody (aa1-237) LS-C185456

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa1-237) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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DIAPH1 Antibody LS-C665086

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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DIAPH1 Antibody LS-C334279

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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DIAPH1 Antibody LS-C482499

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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DIAPH1 Antibody LS-C802786

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DIAPH1 Antibody LS-C341860

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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DIAPH1 Antibody (clone 5A8) LS-C197050

Antibody:

DIAPH1 Mouse anti-Human Monoclonal (5A8) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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DIAPH1 Antibody (aa1200-C-term) LS-C286782

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa1200-C-term) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

1 µg/$295; 100 µl/$532

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DIAPH1 Antibody LS-C310133

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

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DIAPH1 Antibody (HRP) LS-C541801

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$937

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DIAPH1 Antibody (Biotin) LS-C521669

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$937

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DIAPH1 Antibody (FITC) LS-C531713

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$937

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DIAPH1 Antibody (PE) LS-C649913

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$937

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DIAPH1 Antibody (APC) LS-C513455

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$937

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

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DIAPH1 Antibody (aa1196-1245) LS-C151574

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa1196-1245) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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DIAPH1 Antibody (aa389-583) LS-C373652

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa389-583) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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DIAPH1 Antibody (aa389-583, HRP) LS-C714125

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa389-583) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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DIAPH1 Antibody (aa389-583, Biotin) LS-C689123

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa389-583) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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DIAPH1 Antibody (aa389-583, FITC) LS-C696192

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa389-583) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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DIAPH1 Antibody (aa389-583, Cy3) LS-C705111

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa389-583) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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DIAPH1 Antibody (aa389-583, APC, Cy7) LS-C737104

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa389-583) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC, Cy7

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC, Cy7

Select

DIAPH1 Antibody (aa18-52) LS-C344287

Antibody:

DIAPH1 Rabbit anti-Human Polyclonal (aa18-52) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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