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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DIABLO / SMAC Antibody (aa225‑239) LS‑C4 Best Seller
SMAC antibody LS-C4 is an unconjugated rabbit polyclonal antibody to SMAC (DIABLO) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C4-100
100 µg (1 mg/ml)
Unavailable

Popular DIABLO / SMAC Products

Antibody
Species: Human
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Anti-DIABLO / SMAC antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B221 dilution 1:500.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Anti-DIABLO / SMAC antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1350 concentration 5 ug/ml.
Species: Mouse, Human
Applications: IHC, IHC - Paraffin, Western blot
Anti-DIABLO / SMAC antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3668 concentration 10 ug/ml.
Species: Human, Monkey
Applications: IHC, IHC - Paraffin, Western blot

Product Description

SMAC antibody LS-C4 is an unconjugated rabbit polyclonal antibody to SMAC (DIABLO) from human, mouse and rat. Validated for IHC and WB.
About DIABLO / SMAC
Second mitochondria-derived activator of caspase (SMAC) has been implicated in the activation of apoptosis in response to cell stress. SMAC promotes CASP9 activation by binding to IAPs and removing their inhibitory activity. The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. Q9NR28 NM_019887 NP_063940.1

DIABLO Antibody, DFNA64 Antibody, DIABLO-S Antibody, Diablo homolog, mitochondrial Antibody, SMAC3 Antibody, Mitochondrial Smac protein Antibody, SMAC Antibody


Specifications

Target
Human DIABLO / SMAC
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Blocking Peptide
LS-E29958 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-C4. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa225-239
Presentation
PBS, 0.02% sodium azide.
Storage
Store at 4°C for 3 months and -20°C, stable for up to 1 year. Avoid repeated freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.

Western blot

Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.
Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.

Western blot

Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.
Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.

Western blot

Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.
Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.

Western blot

Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.
Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.

Western blot

Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.
Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.

Western blot

Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.
Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 µg/mL.

Immunohistochemistry

Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/ml.

Western blot

Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.
Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1 µg/mL.

Western blot

Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.
Western blot of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug/ml.

Requested From: 
Date Requested: 7/19/2018

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