Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 6A6A3] (IgG2b) to Human DHX58 / LGP2
Flow Cytometry, ELISA
Rabbit Polyclonal (IgG) to Human DHX58 / LGP2
Human DHX58 / LGP2
Human, Rat (tested or 100% immunogen sequence identity)
Monkey, Mouse, Hamster, Rabbit (at least 90% immunogen sequence identity)
Western blot (15 µg/ml)
Specificity and Use
DHX58 / LGP2 antibody was raised against a synthetic peptide corresponding to part of the C-terminal of human LGP2 (IQAKKWSRVPFSV). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey, Rat (100%); Galago, Marmoset, Mouse, Hamster, Rabbit (92%); Ferret, Panda, Dog, Guinea pig (85%).
Human DHX58 / LGP2
Lyophilized from PBS, 1% BSA, 0.05% sodium azide
1 ml Distilled water
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both.