Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Rat (tested or 100% immunogen sequence identity)
Monkey, Mouse, Hamster, Rabbit (at least 90% immunogen sequence identity)
Western blot (15 µg/ml)
Specificity and Use
DHX58 / LGP2 antibody was raised against a synthetic peptide corresponding to part of the C-terminal of human LGP2 (IQAKKWSRVPFSV). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey, Rat (100%); Galago, Marmoset, Mouse, Hamster, Rabbit (92%); Ferret, Panda, Dog, Guinea pig (85%).
Human DHX58 / LGP2
Lyophilized from PBS, 1% BSA, 0.05% sodium azide
1 ml Distilled water
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both.