DGCR8

DGCR8 microprocessor complex subunit

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Involved in the silencing of embryonic stem cells self-renewal.

☰ Filters

Products

Antibodies (35)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (35)

Recombinant (3)

Target

DGCR8 (40)

Reactivity

Human (35)

Mouse (12)

Rat (6)

Bat (1)

Bovine (4)

Chicken (1)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Hamster (1)

Monkey (4)

Pig (4)

Rabbit (1)

Xenopus (1)

more less

Application

IHC (8)

IHC-P (5)

WB (32)

Flo (1)

ELISA (12)

IF (1)

IP (2)

Peptide-ELISA (2)

Host

rabbit (31)

mouse (3)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (25)

IgG1 (1)

IgG2b,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (33)

Clone

4G3 (1)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Preservative Free (1)

Unconjugated (19)

Epitope

aa439-466 (7)

Internal (4)

aa180-229 (4)

aa1-50 (2)

aa400-450 (1)

aa446-460 (1)

pSer377 (1)

Publications

No (40)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

DGCR8 Antibody (aa180-229) LS-B5718

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa180-229) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

DGCR8 Antibody (aa180-229, HRP) LS-C441390

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa180-229) (HRP) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

DGCR8 Antibody (aa180-229, Biotin) LS-C441388

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa180-229) (Biotin) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

DGCR8 Antibody (aa180-229, FITC) LS-C441389

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa180-229) (FITC) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

DGCR8 Antibody LS-C662643

Antibody:

DGCR8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

DGCR8 Antibody (aa1-50) LS-C289204

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

DGCR8 Antibody LS-C804376

Antibody:

DGCR8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

DGCR8 Antibody LS-C753323

Antibody:

DGCR8 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

DGCR8 Antibody (clone 4G3) LS-C134081

Antibody:

DGCR8 Mouse anti-Human Monoclonal (4G3) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

DGCR8 Antibody (aa439-466) LS-C167383

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa439-466) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

DGCR8 Antibody (aa439-466) LS-C327211

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa439-466) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

DGCR8 Antibody (aa439-466, Biotin) LS-C276848

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

DGCR8 Antibody (aa439-466, FITC) LS-C276849

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

DGCR8 Antibody (aa439-466, APC) LS-C276847

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

DGCR8 Antibody (aa439-466, Azide-free, HRP) LS-C276850

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

DGCR8 Antibody (aa439-466, PE) LS-C276851

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

DGCR8 Antibody (aa400-450) LS-C289205

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa400-450) Antibody

Reactivity:

Human

Applications:

IHC, IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

DGCR8 Antibody LS-C753320

Antibody:

DGCR8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

DGCR8 Antibody LS-C753325

Antibody:

DGCR8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

DGCR8 Antibody LS-C137005

Antibody:

DGCR8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$332

Select

DGCR8 Antibody (aa1-50) LS-C286892

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

Select

DGCR8 Antibody (phospho-Ser377) LS-C658668

Antibody:

DGCR8 Rabbit anti-Mouse Polyclonal (pSer377) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$469

Select

DGCR8 Antibody LS-C311087

Antibody:

DGCR8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

DGCR8 Antibody (Internal) LS-C345786

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

DGCR8 Antibody (Preservative Free) LS-C815296

Antibody:

DGCR8 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Viewing 1-25 of 40 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.